NeuroElectro Publications

Article: Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Tai C; Abe Y; Westenbroek RE; Scheuer T; Catterall WA
Proc. Natl. Acad. Sci. U.S.A., 2014

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	adaptation ratio	0.75 ± 0.02 (19)	0.75 (ratio)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	cell capacitance (pF)	29.2 ± 1.0 (19)	29.2 (pF)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	firing frequency (Hz)	57.8 ± 4.5 (19)	57.8 (Hz)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	input resistance (Mohm)	174.1 ± 14.8 (19)	174.1 (MΩ)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	other	0.9 ± 0.03 (19)	0.9 (None)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	resting membrane potential (mV)	-65.5 ± 0.7 (19)	-65.5 (mV)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	rheobase (pA)	178.4 ± 12.0 (19)	178.4 (pA)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	spike amplitude (mV)	56.1 ± 1.4 (19)	56.1 (mV)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	spike half-width (ms)	0.72 ± 0.03 (19)	0.72 (ms)	Data Table
Neocortex basket cell	Somatosensory cortex layer 5 parvalbumin expressing basket cell	spike threshold (mV)	-33.9 ± 1.0 (19)	-33.9 (mV)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	adaptation ratio	0.36 ± 0.03 (21)	0.36 (ratio)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	cell capacitance (pF)	24.8 ± 1.3 (21)	24.8 (pF)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	firing frequency (Hz)	40.9 ± 3.8 (21)	40.9 (Hz)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	input resistance (Mohm)	326.9 ± 29.6 (21)	326.9 (MΩ)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	other	1.01 ± 0.03 (21)	1.01 (None)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	resting membrane potential (mV)	-73.2 ± 1.0 (21)	-73.2 (mV)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	rheobase (pA)	51.9 ± 6.6 (21)	51.9 (pA)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	spike amplitude (mV)	86.5 ± 1.7 (21)	86.5 (mV)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	spike half-width (ms)	1.49 ± 0.08 (21)	1.49 (ms)	Data Table
Neocortex Martinotti cell	Somatosensory cortex layer 5 somatostatin expressing Martinotti cell	spike threshold (mV)	-38.3 ± 1.0 (21)	-38.3 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	adaptation ratio	0.85 ± 0.03 (35)	0.85 (ratio)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	cell capacitance (pF)	39.2 ± 1.8 (35)	39.2 (pF)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	firing frequency (Hz)	14.2 ± 1.5 (35)	14.2 (Hz)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	input resistance (Mohm)	260.0 ± 20.4 (35)	260.0 (MΩ)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	other	0.92 ± 0.04 (35)	0.92 (None)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	resting membrane potential (mV)	-58.2 ± 0.6 (35)	-58.2 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	rheobase (pA)	98.6 ± 5.5 (35)	98.6 (pA)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	spike amplitude (mV)	81.8 ± 0.9 (35)	81.8 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	spike half-width (ms)	2.1 ± 0.09 (35)	2.1 (ms)	Data Table
Neocortex pyramidal cell layer 5-6	Somatosensory cortex layer 5 pyramidal cell	spike threshold (mV)	-32.1 ± 1.0 (35)	-32.1 (mV)	Data Table

Metadata values

Experimental condition	Value
Species	Mice
Strain	C57BL
Strain	Mouse, Transgenic
ElectrodeType	Patch-clamp
PrepType	in vitro
JxnPotential	Unreported
AnimalAge	20.0 - 22.0
RecTemp	22.0 - 24.0
internal_0_pH	7.2
internal_0_Mg	4.0
internal_0_Na	0.5
internal_0_K	140.0
internal_0_GTP	0.5
internal_0_ATP	4.0
internal_0_EGTA	1.1
internal_0_HEPES	10.0
internal_0_Cl	0.2
internal_0_Ca	0.1
InternalSolution	5.0
external_0_pH	7.3
external_0_Mg	2.0
external_0_Na	153.25
external_0_K	2.5
external_0_Cl	136.5
external_0_Ca	2.0
external_0_glucose	10.0
ExternalSolution	5.0

Data table listing

Data Table	Article Title	Authors	Journal	Year	Table needs expert?	Ephys table mentions	Curated by	Times validated
50033	Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.	Tai C; Abe Y; Westenbroek RE; Scheuer T; Catterall WA	Proc. Natl. Acad. Sci. U.S.A.	2014	False	10	Shreejoy Tripathy, Brenna Li,	3
50032	Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.	Tai C; Abe Y; Westenbroek RE; Scheuer T; Catterall WA	Proc. Natl. Acad. Sci. U.S.A.	2014	False	0		None