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Article: Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Zhang W; Zhang L; Liang B; Schroeder D; Zhang ZW; Cox GA; Li Y; Lin DT Nat. Neurosci., 2016
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 5-6 | primary motor cortex layer 5 corticospinal thick tufted pyramidal cell | input resistance (Mohm) | 92.6 ± 5.0 (29) | 92.6 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | primary motor cortex layer 5 corticospinal thick tufted pyramidal cell | resting membrane potential (mV) | -62.5 ± 1.6 (29) | -62.5 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | primary motor cortex layer 5 corticospinal thick tufted pyramidal cell | spike threshold (mV) | -40.0 ± 0.9 (29) | -40.0 (mV) | Data Table |
Metadata values
| Experimental condition | Value |
|---|---|
| Species | Mice |
| Strain | C57BL |
| ElectrodeType | Patch-clamp |
| PrepType | in vitro |
| JxnPotential | Unreported |
| AnimalAge | 20.0 - 22.0 |
| RecTemp | 32.0 - 33.0 |
| InternalSolution | 5.0 |
| ExternalSolution | 5.0 |
| internal_0_pH | 7.2 |
| internal_0_Mg | 4.0 |
| internal_0_K | 130.0 |
| internal_0_GTP | 0.3 |
| internal_0_ATP | 4.0 |
| internal_0_EGTA | 0.5 |
| internal_0_HEPES | 10.0 |
| internal_0_Cl | 10.0 |
| external_0_Mg | 1.3 |
| external_0_Na | 151.0 |
| external_0_K | 3.0 |
| external_0_Cl | 132.6 |
| external_0_Ca | 1.5 |
| external_0_glucose | 20.0 |
Data table listing
| Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
|---|---|---|---|---|---|---|---|---|
| 50030 | Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders. | Zhang W; Zhang L; Liang B; Schroeder D; Zhang ZW; Cox GA; Li Y; Lin DT | Nat. Neurosci. | 2016 | False | 3 | Shreejoy Tripathy, Dawson Born, | 2 |