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Article: Maternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Lin M; Chen QH; Wurster RD; Hatcher JT; Liu YQ; Li L; Harden SW; Cheng ZJ J. Neurophysiol., 2010
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Nucleus ambiguus motor neuron | cell capacitance (pF) | 60.8 ± 2.8 (15) | 60.8 (pF) | Data Table | |
| Nucleus ambiguus motor neuron | input resistance (MΩ) | 246.6 ± 19.0 (15) | 246.6 (MΩ) | Data Table | |
| Nucleus ambiguus motor neuron | resting membrane potential (mV) | -70.3 ± 1.1 (17) | -70.3 (mV) | Data Table | |
| Nucleus ambiguus motor neuron | spike amplitude (mV) | 85.5 ± 2.0 (15) | 85.5 (mV) | Data Table | |
| Nucleus ambiguus motor neuron | spike threshold (mV) | -40.8 ± 1.2 (10) | -40.8 (mV) | Data Table |
Metadata values
| Experimental condition | Value |
|---|---|
| Species | Mice |
| ElectrodeType | Patch-clamp |
| PrepType | in vitro |
| Strain | Mouse, Transgenic |
| RecTemp | 22.0 - 25.0 |
| AnimalAge | 7.0 - 9.0 |
| ExternalSolution | 5.0 |
| InternalSolution | 5.0 |
| external_1_pH | 7.4 |
| external_1_Mg | 1.0 |
| external_1_Ca | 2.0 |
| external_1_Na | 140.0 |
| external_1_Cl | 149.0 |
| external_1_K | 3.0 |
| internal_1_pH | 7.3 |
| internal_1_Mg | 2.0 |
| internal_1_Na | 5.0 |
| internal_1_Cl | 19.0 |
| internal_1_K | 120.0 |
| JxnPotential | Not corrected |
| internal_0_pH | 7.3 |
| internal_0_Mg | 2.0 |
| internal_0_K | 140.0 |
| internal_0_GTP | 0.25 |
| internal_0_ATP | 2.0 |
| internal_0_EGTA | 0.1 |
| internal_0_HEPES | 10.0 |
| internal_0_Cl | 24.0 |
| external_0_pH | 7.4 |
| external_0_Mg | 2.0 |
| external_0_Na | 153.25 |
| external_0_K | 2.5 |
| external_0_Cl | 132.5 |
| external_0_Ca | 2.0 |
| external_0_glucose | 10.0 |
Data table listing
| Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
|---|---|---|---|---|---|---|---|---|
| 133 | Maternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus. | Lin M; Chen QH; Wurster RD; Hatcher JT; Liu YQ; Li L; Harden SW; Cheng ZJ | J. Neurophysiol. | 2010 | False | 5 | Shreejoy Tripathy, Nathalie Binnion, Brenna Li, | 2 |
| 132 | Maternal diabetes increases small conductance Ca2+-activated K+ (SK) currents that alter action potential properties and excitability of cardiac motoneurons in the nucleus ambiguus. | Lin M; Chen QH; Wurster RD; Hatcher JT; Liu YQ; Li L; Harden SW; Cheng ZJ | J. Neurophysiol. | 2010 | False | 0 | None |