Passive and active membrane properties of control and vagotomized nodose neurons in intact nodose ganglia
| Control | Vagotomy | |
|---|---|---|
| Passive properties | ||
| R in, MΩ | 62 ± 10 (19) | 38 ± 6 (21) |
| E m, mV | −51 ± 2 (20) | −56 ± 2 (23) |
| Firing properties | ||
| AP rheobase, pA | 574 ± 70 (18) | 631 ± 100 (22) |
| 1 times threshold (APs) | 1 ± 0 (20) | 1 ± 0 (23) |
| 2 times threshold (APs) | 5 ± 1 (20) | 1 ± 0 (23)* |
| 3 times threshold (APs) | 10 ± 2 (20) | 1 ± 0 (23)† |
| 1 nA (APs) | 7 ± 2 (13) | 1 ± 0 (17)‡ |
| 2 nA (APs) | 15 ± 3 (13) | 1 ± 0 (17)* |
| 3 nA (APs) | 14 ± 3 (13) | 1 ± 0 (16)* |
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Values are means ± SE; numbers in parentheses are number of neurons for each measurement. Properties of control and vagotomized nodose neurons in intact nodose ganglia. R in, membrane input resistance; E m, resting membrane potential; AP threshold (rheobase), the minimum amount of current required to evoke a single AP; 1, 2, and 3 times threshold (APs), the number of APs fired in response to a single 750-ms depolarizing current step of, respectively, 1, 2, and 3 times threshold intensity; 1, 2, and 3 nA (APs), the number of APs elicited by 750-ms depolarizing current steps of those magnitudes. Values of NGNs in 3 vagotomized ganglia were compared to values of NGNs in the 3 contralateral control ganglia using 2-way ANOVA (as described in methods). * P< 0.001. † P < 0.01. ‡ P < 0.05.