Membrane properties of CA1 neurons before and after ischemia
| RMP, mV | SpkH, mV | SpkD, ms | SpkT, mV | Rheobase, nA | Rin, MΩ | Tcons, ms | fAHP, mV | |
|---|---|---|---|---|---|---|---|---|
| Control | −68 ± 1.62 (12) | 88 ± 2.23 (13) | 1.11 ± 0.06 (13) | −54 ± 0.86 (13) | 0.3 ± 0.03 (18) | 28 ± 1.35 (20) | 9.81 ± 0.66 (15) | 4.7 ± 0.37 (20) |
| Ischemia | −62 ± 1.93* (17) | 83 ± 1.62 (22) | 0.95 ± 0.05* (22) | −51 ± 1.15* (20) | 0.7 ± 0.09* (22) | 23 ± 1.25* (22) | 7.91 ± 0.62* (15) | 9.4 ± 0.48* (26) |
-
Values are means ± SE, with number of neurons in parentheses. Rheobase is determined as the minimal intensity of depolarizing current pulse to trigger action potentials. Input resistant (R in) is derived from the linear portion of the current-voltage curve (0–0.5 nA). Time constant (T cons) is derived from transients of hyperpolarizing pulse (−0.3 nA, 200 ms). RMP, resting membrane potential; SpkH, spike height, measured from the resting membrane potential; SpkD, spike width measured at half of the peak amplitude of the action potential; SpkT, spike threshold measured at the beginning of the upstroke of the first action potential; fAHP, fast afterhyperpolarization. * P < 0.05.