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Article: Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Zhang JM; Song XJ; LaMotte RH
J. Neurophysiol., 1999


Table 1.

Electrophysiological characteristics of DRG cells from control and injured (CCD) ganglia

Small Medium Large
Control CCD Control CCD Control CCD
Cell size, μm 28.96 ± 0.38 28.52  ± 0.38 40.95  ± 0.91 38.46  ± 0.85 54.81  ± 1.12 54.27  ± 0.82
 n 26 36 27 26 24 47
V m, mV −61.94 ± 1.69 −61.2  ± 1.67 −63.91  ± 1.43 −64.50  ± 1.30 −66.67  ± 1.43 −66.2  ± 1.29
 n 26 36 27 16 24 47
AP threshold, mV −27.79 ± 2.87 −35.29  ± 1.49* −37.51  ± 1.20 −42.00  ± 1.94* −40.45  ± 2.69 −50.83  ± 1.43**
 n 26 32 27 26 23 45
AP duration, ms 3.26 ± 0.24 3.38  ± 0.29 1.96  ± 0.13 2.27  ± 0.23 0.99  ± 0.09 1.0  ± 0.07
 n 26 34 27 16 23 45
Threshold current, nA 0.90 ± 0.08 0.58  ± 0.05** 1.68  ± 0.14 0.72  ± 0.08** 1.89  ± 0.21 0.95  ± 0.11**
 n 26 34 27 26 24 46
AHP amplitude, mV 15.51 ± 1.03 15.2  ± 0.89 12.94  ± 1.17 13.9  ± 1.06 12.10  ± 0.67 12.8  ± 0.88
 n 26 34 27 26 22 45
AHP duration, ms 4.49 ± 0.35 4.18  ± 0.33 2.42  ± 0.16 4.47  ± 0.63** 2.04  ± 0.22 2.15  ± 0.17
 n 26 34 27 26 22 45
Vmax mV/ms 188.45 ± 13.3 159.9  ± 12.0 191.9  ± 20.6 217.2  ± 22.9 298.9  ± 19.9 335.5  ± 19.4
 n 26 34 25 26 17 46
AP amplitude, mV 56.1 ± 2.0 61.2  ± 7.3 55.1  ± 2.2 62.8  ± 2.7* 56  ± 2.5 61.3  ± 1.9
 n 26 34 25 26 24 39
CV, m/s 1.0 ± 0.13 1.13  ± 0.15 8.62  ± 2.13 8.42  ± 1.49 34.57  ± 3.94 35.60  ± 4.75
 n 8 9 6 8 15 15
Rin MΩ 99.31 ± 14.31 105.0  ± 11.0 37.08  ± 3.28 56.7  ± 6.58 34.46  ± 6.01 32.90  ± 2.37
 n 20 34 17 26 17 46

  • Values are means ± SE and n = sample size. DRG, dorsal root ganglion; CCD, chronically compressed DRG;V m, resting membrane potential; AP, action potential; AHP, after hyperpolarization; R in, input resistance; CV, conduction velocity; V max, maximum depolarization rate. * P < 0.05; ** P < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell spike amplitude (mV) 56.1 ± 2.0 56.1 (mV) Data Table
Dorsal root ganglion cell spike amplitude (mV) 55.1 ± 2.2 55.1 (mV) Data Table
Dorsal root ganglion cell spike amplitude (mV) 56.0 ± 2.5 56.0 (mV) Data Table
Dorsal root ganglion cell input resistance (MΩ) 99.31 ± 14.31 99.31 (MΩ) Data Table
Dorsal root ganglion cell input resistance (MΩ) 37.08 ± 3.28 37.08 (MΩ) Data Table
Dorsal root ganglion cell input resistance (MΩ) 34.46 ± 6.01 34.46 (MΩ) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -61.94 ± 1.69 -61.94 (mV) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -63.91 ± 1.43 -63.91 (mV) Data Table
Dorsal root ganglion cell cell diameter (μm) 28.96 ± 0.38 28.96 (um) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -66.67 ± 1.43 -66.67 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -27.79 ± 2.87 -27.79 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -37.51 ± 1.2 -37.51 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -40.45 ± 2.69 -40.45 (mV) Data Table
Dorsal root ganglion cell cell diameter (μm) 40.95 ± 0.91 40.95 (um) Data Table
Dorsal root ganglion cell spike width (ms) 3.26 ± 0.24 3.26 (ms) Data Table
Dorsal root ganglion cell spike width (ms) 1.96 ± 0.13 1.96 (ms) Data Table
Dorsal root ganglion cell spike width (ms) 0.99 ± 0.09 0.99 (ms) Data Table
Dorsal root ganglion cell rheobase (nA) 0.9 ± 0.08 900.0 (pA) Data Table
Dorsal root ganglion cell cell diameter (μm) 54.81 ± 1.12 54.81 (um) Data Table
Dorsal root ganglion cell rheobase (nA) 1.68 ± 0.14 1680.0 (pA) Data Table
Dorsal root ganglion cell rheobase (nA) 1.89 ± 0.21 1890.0 (pA) Data Table
Dorsal root ganglion cell AHP amplitude (mV) 15.51 ± 1.03 15.51 (mV) Data Table
Dorsal root ganglion cell AHP amplitude (mV) 12.94 ± 1.17 12.94 (mV) Data Table
Dorsal root ganglion cell AHP amplitude (mV) 12.1 ± 0.67 12.1 (mV) Data Table
Dorsal root ganglion cell AHP duration (ms) 4.49 ± 0.35 4.49 (ms) Data Table
Dorsal root ganglion cell AHP duration (ms) 2.42 ± 0.16 2.42 (ms) Data Table
Dorsal root ganglion cell AHP duration (ms) 2.04 ± 0.22 2.04 (ms) Data Table