E16 | E18 | P0–P1 | |
---|---|---|---|
Action potential amplitude, mV | 66.5 ± 2.0 | 68.1 ± 1.6 | 78.3 ± 2.5* |
Action potential duration, ms† | 6.2 ± 0.5 | 4.1 ± 0.3‡ | 3.2 ± 0.2‡ § |
Resting membrane potential, mV | −49.3 ± 5.9 | −57.4 ± 2.0 | −59.3 ± 1.2* |
Input resistance, MΩa | 806 ± 81 | 551 ± 61* | 266 ± 33‡ § |
Mean rheobase, pAb | 35 ± 4 | 42 ± 6 | 89 ± 14‡ § |
Time constant, msc | 53.0 ± 4.6 | 46.0 ± 5.0 | 38.0 ± 3‡ |
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↵† Action potential duration at half-maximal amplitude; * P ≤ 0.05; ‡ P ≤ 0.01 vs. E16; § P ≤ 0.05 vs. E18. a Input resistance was calculated from the voltage responses to injections of small hyperpolarizing current pulses (400 ms, 10–30 nA). b Mean rheobase was determined by dividing the threshold potential by input resistance. c Time constant was obtained by fitting the voltage transient induced by the injection of hyperpolarizing current to an exponential function.