Article: Ionic mechanism of electroresponsiveness in cerebellar granule cells implicates the action of a persistent sodium current.

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D'Angelo E; De Filippi G; Rossi P; Taglietti V
J. Neurophysiol., 1998

Table 2.

Action potential changes during TEA, ω-CTX GVIA, and ChTX application

	n	Overshoot	Undershoot	HW	Rising Rate	Falling Rate
TEA	6	0.09 ± 0.09^*	−0.61 ± 0.14^†	0.340.21^†	0.07 ± 0.1	−0.32 ± 0.07
ω-CTx-GVIA	5	−0.28 ± 0.2^*	−0.71 ± 0.31^†	0.22 ± 0.18^*	−0.26 ± 0.25	−0.44 ± 0.2^†
ChTX	4	−0.14 ± 0.12	−0.63 ± 0.28^*	0.18 ± 0.06^*	−0.06 ± 0.07	−0.21 ± 0.14^*

Application of tetraethylammonium (TEA, 0.5 mM), ω-CTX GVIA (5 μM), or charibdotoxin ChTX; 50 nM) broadened the spike reducing the falling rate and the undershoot, suggesting a common action on I _KCa. Moreover, ω-CTX GVIA reduced the overshoot, suggesting an involvement of I _Ca in spike generation, whereas TEA increased the overshoot, suggesting an involvement of I _KV in early spike repolarization. Data are reported as percent changes compared with control, and statistical significance of the changes is indicated (* P < 0.05;
↵† P < 0.01). Data without symbols were considered not significant.

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source