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Article: Responses of deep entorhinal cortex are epileptiform in an electrogenic rat model of chronic temporal lobe epilepsy.

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Fountain NB; Bear J; Bertram EH; Lothman EW
J. Neurophysiol., 1998


Table 2.

Characteristics of deep layer EC intracellular evoked responses

Control Epileptic
n * 30 44
Total duration of depolarization, ms 8.6 ± 1.3 256 ± 39
Number of APs per response 1 ± 0 13 ± 4
Clonic response present, % 0 10
With GABAA and GABAB IPSPs,ρ % 77 0
With GABAA IPSP only,ρ % 13 0
Without IPSPs, % 10 100
AP stimulation threshold to angular bundle stimulation, V 40 ± 6.0 21 ± 6.17
AP stimulation threshold to superficial stimulation, V 7.8 ± 3.4 6.8 ± 1.8
  • Values for continuous variable are means ± SE. Continuous variables compared by ANOVA and proportions compared by Fisher's exact test. AP, action potential; GABAA and GABAB, γ-amino butyric acid-A and -B.

  • * n, number of responses with the given inhibitory postsynaptic potential (IPSP).  Difference between control and epileptic is statistically significant at P < 0.05.  Difference between control and epileptic is statistically significant at P < 0.001. ρ GABAA and GABAB are early and late IPSPs, respectively.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Entorhinal cortex layer IV neuron spike width (ms) 8.6 ± 1.3 -- Data Table
Entorhinal cortex layer IV neuron spike threshold (V) 40.0 ± 6.0 -- Data Table
Entorhinal cortex layer IV neuron spike threshold (V) 7.8 ± 3.4 -- Data Table