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Article: Altered information processing in the prefrontal cortex of Huntington's disease mouse models.

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Walker AG; Miller BR; Fritsch JN; Barton SJ; Rebec GV
J. Neurosci., 2008


Table 1.

Spike train variability and burst structure for transgenic and knock-in mouse models of HD and corresponding WT littermates

WT R6/2 or KI
Median Range 25th to 75th percentile Median Range 25th to 75th percentile
Transgenic model (R6/2)
    Variability
        CV ISI 1.338* 1.005–9.583 1.198–1.579 1.258 0.929–3.688 1.147–1.417
    Burst structure
        Duration (s) 1.283† 0.191–14.07 0.759–2.288 1.006 0.166–34.90 0.062–2.128
        Spikes/s 24.92† 2.579–160.3 14.71–43.39 31.85 1.473–114.8 16.90–49.64
        Spikes/burst 15.67 5.00–60.38 12.56–20.81 16.27 6.00–87.40 13.00–21.38
        ISI in a burst (s) 0.098† 0.012–0.996 0.049–0.137 0.068 0.012–0.927 0.036–0.126
Knock-in model (KI)
    Variability
        CV ISI 1.28 0.097–11.83 1.158–1.50 1.316 1.030–3.289 1.201–1.583
    Burst structure
        Duration (s) 0.832 0.067–187.4 0.548–1.566 0.787 0.156–54.68 0.488–1.148
        Spikes/s 40.95 0.176–123.5 25.21–58.77 38.91 0.463–180.0 21.38–58.79
        Spikes/burst 15.59 4.80–48.63 12.54–19.82 15.15 7.054–36.11 12.67–19.84
        ISI in a burst (s) 0.057 0.014–5.680 0.039–0.096 0.053 0.008–3.212 0.034–0.102

  • ↵*p < 0.01, significant difference between medians of R6/2 and WT.

  • ↵†p < 0.0001, significant differences between medians of WT mice from the transgenic and WT mice of the KI line.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex uncharacterized cell spike width (s) 1.283 1.283 (ms) Data Table
Neocortex uncharacterized cell spike width (s) 0.832 0.832 (ms) Data Table