Table 2.
Comparison of membrane properties in visually identified layer V cortical pyramidal neurons in developing +/+ and stg/stg at postnatal day 18–20
| +/+ | stg/stg | P | |
|---|---|---|---|
| V r, mV | −70.2 ± 2.1 (7) | −71.7 ± 1.7 (6) | ns |
| R in, MΩ | 142 ± 30 (7) | 147 ± 28 (6) | ns |
| Sag amplitude, mV | 2.1 ± 0.8 (4) | 9.0 ± 1.2 (4) | <0.001 |
| [↑428%] | |||
| Inward rectifier amplitude, pA | 76.8 ± 14.4 [35–124] (7) | 221.0 ± 44.2 [108–341] (6) | <0.01 |
| [↑290%] | |||
| Cell capacitance, pF | 34.6 ± 3.1 (7) | 30.0 ± 5.2 (6) | ns |
| Inward rectifier current density, pA/pF | 2.1 ± 0.5 (7) | 6.2 ± 0.9 (6) | <0.005 |
| [↑295%] | |||
| τ, ms, at −110 mV | 252.6 ± 17.4 | 289.5 ± 12.5 | ns |
| τ, ms, at −120 mV | 157.3 ± 12.7 (4) | 157.0 ± 22.4 (4) | |
| V 1/2, mV | −93.9 ± 1.4 (3) | −93.8 ± 1.6 (4) | ns |
-
Values, except for P values, are means ± SE, with number of neurons in parentheses. Values in brackets in +/+ and stg/stg columns are ranges. τ, single-exponential fit time constant; V 1/2, inward rectifier half activation; for remaining abbreviations, see Table 1.