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Article: Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life.

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Schridde U; Strauss U; Bräuer AU; van Luijtelaar G
Eur. J. Neurosci., 2006


Table 1.   General current-clamp properties of layer 5 pyramidal neurons from somatosensory cortex of WAG/Rij rats raised under different rearing conditions
 Control(n)MD(n)NH(n)

  1. Data presented as the mean ± SEM (n, number of cells), *P < 0.05 and **P < 0.01 when compared to neurons from nontreated WAG/Rij rats (control). Note that I–ƒ slopes and rheobases were gathered in ACSF, whereas ‘sags’ and afterpotentials are taken from measurements in DCS. ZD7288-DCS indicates the difference between the respective membrane potentials.

RMP (mV)
  ACSF−68.1 ± 0.7823−68.4 ± 0.7823−69.5 ± 0.8821
  DCS−64.2 ± 0.9212−60.4 ± 1.15*15−60.6 ± 1.1*12
  ZD7288-DCS0.8 ± 0.816−4.2 ± 1.5*9−5.1 ± 1.17*6
RN (MΩ)
  ACSF201.7 ± 14.323150.0 ± 8.8*23119.0 ± 15.2**21
  DCS264.4 ± 15.912212.1 ± 15.6*15177.0 ± 17.3**12
  ZD7288311.9 ± 39.06331.6 ± 48.09307.6 ± 82.16
τM (ms)
  ACSF29.2 ± 1.692322.4 ± 1.27**2321.6 ± 1.22**21
  DCS47.2 ± 1.71238.9 ± 2.71*1536.9 ± 1.5*12
  ZD728855.6 ± 5.1660.2 ± 4.54958.3 ± 4.916
‘Sag’ at −100 ± 3 mV (mV)−4.1 ± 0.8812−6.9 ± 0.7*15−7.8 ± 0.77**12
Afterpotential post −100 ± 3 mV (mV)3.6 ± 0.44125.6 ± 0.48**157.2 ± 0.34**12
I–ƒ slope (Hz/nA)90.9 ± 7.762368.1 ± 4.81*2371.1 ± 4.01*21
Rheobase – action potential current threshold (pA)38.2 ± 5.242376.4 ± 9.49*2386.7 ± 15.83*21

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Somatosensory cortex pyramidal neuron layer 5 input resistance 201.7 ± 14.3 (23) 201.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex pyramidal neuron layer 5 resting membrane potential -68.1 ± 0.78 (23) -68.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex pyramidal neuron layer 5 membrane time constant 29.2 ± 1.69 (23) 29.2 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex pyramidal neuron layer 5 FI slope (Hz/nA) 90.9 ± 7.76 (23) 90.9 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex pyramidal neuron layer 5 rheobase (pA) 38.2 ± 5.24 (23) 38.2 (pA) Data Table