Article: Neuregulin-1 signals from the periphery regulate AMPA receptor sensitivity and expression in GABAergic interneurons in developing neocortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Abe Y; Namba H; Kato T; Iwakura Y; Nawa H J. Neurosci., 2011
Electrophysiologic properties of fast-spiking neurons
Control (n = 20) | eNRG1 (n = 20) | |
---|---|---|
Series resistance (MΩ) | 16.0 ± 0.8 | 15.6 ± 0.8 |
Input resistance (MΩ) | 258 ± 23 | 274 ± 20 |
Capacitance (pF) | 115 ± 7 | 113 ± 4 |
AHP amplitude (mV) | −22.4 ± 0.9 | −20.5 ± 0.6 |
Voltage sag (mV) | −8.7 ± 1.8 | −8.8 ± 1.1 |
Resting potential (mV) | −59.1 ± 1.0 | −56.5 ± 1.3 |
AP frequency (Hz) | 78.1 ± 2.4 | 78.7 ± 2.4 |
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Input resistance and series resistance were determined by measuring the current response to a −5 mV pulse from the holding potential. Cell capacitance measurements were made by integrating capacitive transients. Afterhyperpolarization (AHP) was determined after the first action potential (AP) triggered by the minimum depolarizing current (100–300 pA). Voltage sag was determined by measuring voltage responses to a hyperpolarizing current (−400 pA, 450 ms). Action potentials were generated by current injection (800 pA, 450 ms), and their frequency was measured. No statistical differences were detected in these electrophysiologic properties.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neocortex basket cell | frontal cortex fast spiking neuron | AHP amplitude (mV) | -22.4 ± 0.9 (20) | 22.4 (mV) | Data Table |
Neocortex basket cell | frontal cortex fast spiking neuron | sag amplitude (mV) | -8.7 ± 1.8 (20) | -8.7 (mV) | Data Table |
Neocortex basket cell | frontal cortex fast spiking neuron | resting membrane potential (mV) | -59.1 ± 1.0 (20) | -59.1 (mV) | Data Table |
Neocortex basket cell | frontal cortex fast spiking neuron | access resistance (MΩ) | 16.0 ± 0.8 (20) | 16.0 (MΩ) | Data Table |
Neocortex basket cell | frontal cortex fast spiking neuron | firing frequency (Hz) | 78.1 ± 2.4 (20) | 78.1 (Hz) | Data Table |
Neocortex basket cell | frontal cortex fast spiking neuron | input resistance (MΩ) | 258.0 ± 23.0 (20) | 258.0 (MΩ) | Data Table |
Neocortex basket cell | frontal cortex fast spiking neuron | cell capacitance (pF) | 115.0 ± 7.0 (20) | 115.0 (pF) | Data Table |