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Article: Increased intrinsic excitability of lateral wing serotonin neurons of the dorsal raphe: a mechanism for selective activation in stress circuits.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Crawford LK; Craige CP; Beck SG
J. Neurophysiol., 2010


Table 1.

Membrane characteristics of 5-HT neurons of the vmDR and lwDR

RMP, mV Res, MOhm Tau, ms AP Thr, mV AP Amp, mV AP Dur, ms AHP Amp, mV AHP t1/2, ms
vmDR −66.2 ± 2.1 432.4 ± 34.9 23.4 ± 1.9 −20.5 ± 1.3 56.6 ± 1.6 1.8 ± 0.1 29.4 ± 1.1 149.1 ± 13.0
lwDR −63.3 ± 1.9 592.0 ± 70.2 30.6 ± 2.4* −25.1 ± 1.2* 62.2 ± 1.7* 2.4 ± 0.1** 33.7 ± 1.6* 224.9 ± 14.4***
  • Values are means ± SE; vmDR, n = 19; lwDR, n = 17.

  • * P < 0.05;

  • ** P < 0.01;

  • *** P < 0.001. RMP, resting membrane potential; Res, resistance; AP Thr, action potential threshold; AP Amp, AP amplitude; AP Dur, AP duration; AHP Amp, afterhyperpolarization amplitude; AHP t1/2, AHP duration measured at half-height.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Lateral wing of serotonin releasing dorsal raphe neurons resting membrane potential (mV) -63.3 ± 1.9 (17) -63.3 (mV) Data Table
Other Lateral wing of serotonin releasing dorsal raphe neurons input resistance 592.0 ± 70.2 (17) 592.0 (MΩ) Data Table
Other Lateral wing of serotonin releasing dorsal raphe neurons membrane time constant (ms) 30.6 ± 2.4 (17) 30.6 (ms) Data Table
Other Lateral wing of serotonin releasing dorsal raphe neurons spike threshold (mV) -25.1 ± 1.2 (17) -25.1 (mV) Data Table
Other Lateral wing of serotonin releasing dorsal raphe neurons spike amplitude (mV) 62.2 ± 1.7 (17) 62.2 (mV) Data Table
Other Lateral wing of serotonin releasing dorsal raphe neurons spike width (ms) 2.4 ± 0.1 (17) 2.4 (ms) Data Table
Other Lateral wing of serotonin releasing dorsal raphe neurons AHP amplitude (mV) 33.7 ± 1.6 (17) 33.7 (mV) Data Table
Other Lateral wing of serotonin releasing dorsal raphe neurons AHP duration (ms) 224.9 ± 14.4 (17) 224.9 (ms) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe resting membrane potential (mV) -66.2 ± 2.1 (19) -66.2 (mV) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe input resistance 432.4 ± 34.9 (19) 432.4 (MΩ) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe membrane time constant (ms) 23.4 ± 1.9 (19) 23.4 (ms) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe spike threshold (mV) -20.5 ± 1.3 (19) -20.5 (mV) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe spike amplitude (mV) 56.6 ± 1.6 (19) 56.6 (mV) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe spike width (ms) 1.8 ± 0.1 (19) 1.8 (ms) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe AHP amplitude (mV) 29.4 ± 1.1 (19) 29.4 (mV) Data Table
Other Ventral wing serotonin releasing neurons of dorsal raphe AHP duration (ms) 149.1 ± 13.0 (19) 149.1 (ms) Data Table