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Article: Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells: relevance for hippocampal theta rhythm.

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Huh CY; Goutagny R; Williams S
J. Neurosci., 2010


Table 1.

Electrophysiological properties of VGLUT2-eGFP-(+) MS-DBB neurons in mouse coronal brain slices, total number of neurons recorded = 66

Firing pattern Cluster firing Fast firing Burst firing Slow firing
Large sag No sag
N (% of total number) 13 (19.7%) 12 (18.2%) 19 (28.8%) 11 (16.7%) 11 (16.7%)
Vrest (mV) −53.0 ± 1.6 −50.3 ± 1.0a −51.5 ± 1.3 −52.0 ± 0.9a −49.5 ± 1.0
Proportion of spontaneous firing 46.2% 50.0% 58.8% 54.5% 18.2%
    Mean frequency (Hz) 2.8 ± 0.7 3.7 ± 1.3 4.6 ± 1.2 2.5 ± 0.6 3.5 ± 0.5
    Range (Hz) 1–6 1–9 1–10 1–5 3–4
Mean firing rate (Hz) 8.8 ± 1.2b,c 15.8 ± 1.6d,e,f 13.6 ± 1.8d,e,f 9.1 ± 0.9b,c 5.3 ± 0.3b,c
FINITIAL (Hz) 12.7 ± 2.2 18.3 ± 2.3f 15.8 ± 1.9f 12.3 ± 1.6 5.9 ± 0.6b,c
FFINAL (Hz) 6.2 ± 1.3b,c 15.4 ± 2.1d,e,f 13.4 ± 1.7d,e,f 7.7 ± 1.0b,c 4.1 ± 0.6b,c
Spike frequency accomodation (%) 51.8 ± 10.4b,c 15.4 ± 6.2d 13.4 ± 3.8d 37.3 ± 9.1 27.3 ± 12.4
Spike threshold (mV) −41.2 ± 0.9 −43.1 ± 1.0 −44.1 ± 1.2f −43.9 ± 1.3f −38.9 ± 1.1c,e
Spike amplitude (mV) 78.1 ± 2.9 80.7 ± 2.0 79.8 ± 2.2 81.9 ± 3.4 76.6 ± 2.2
Spike half-width (ms) 1.3 ± 0.1 1.3 ± 0.1 1.3 ± 0.1 1.2 ± 0.1f 1.7 ± 0.1e
AHP amplitude (mV) 7.5 ± 1.5 5.9 ± 0.9 8.1 ± 0.6 4.9 ± 0.6 7.4 ± 0.9
AHP duration (ms) 253.2 ± 39.9 262.8 ± 31.4 284.5 ± 34.1 292.6 ± 20.8a 318.9 ± 31.1
Sag amplitude (mV) 6.4 ± 1.3b 16.1 ± 1.4c,d,e,f 4.6 ± 0.7b 3.2 ± 1.1a,b 4.9 ± 1.4b
Rebound spike delay (ms) 124.5 ± 42.6 221.7 ± 87.1 94.2 ± 18.4 74.7 ± 7.9 74.3 ± 6.1a
Sag activation time (ms) 131.1 ± 21.3
Sag decay constant (ms) 176.9 ± 19.5
Subthreshold oscillation frequency (Hz) 17.8 ± 2.4
Intracluster/burst frequency (Hz) 15.8 ± 2.2 58.6 ± 11.4
No. of spikes per cluster/burst 4.9 ± 0.6 2.3 ± 0.3
LTS amplitude (mV) 15.3 ± 1.2a
LTS duration (ms) 162.7 ± 39.5
  • Values are given as mean ± SE. Statistically significant differences (p < 0.05) are indicated as follows: aversus GAD65-eGFP-(+) cells with a similar firing pattern bversus fast-firing cells with large sag; cversus fast-firing cells with no sag; dversus cluster-firing cells; eversus burst-firing cells; fversus slow-firing cells.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells resting membrane potential (mV) -51.5 ± 1.3 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells resting membrane potential (mV) -52.0 ± 0.9 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells resting membrane potential (mV) -49.5 ± 1.0 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spontaneous firing rate (Hz) 2.8 ± 0.7 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spontaneous firing rate (Hz) 3.7 ± 1.3 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spontaneous firing rate (Hz) 4.6 ± 1.2 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spontaneous firing rate (Hz) 2.5 ± 0.6 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spontaneous firing rate (Hz) 3.5 ± 0.5 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells firing frequency (Hz) 8.8 ± 1.2 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells firing frequency (Hz) 15.8 ± 1.6 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells firing frequency (Hz) 13.6 ± 1.8 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells firing frequency (Hz) 9.1 ± 0.9 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells firing frequency (Hz) 5.3 ± 0.3 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells adaptation percent (1 – first/last ISI) 51.8 ± 10.4 (13) 51.8 (ratio) Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells adaptation percent (1 – first/last ISI) 15.4 ± 6.2 (12) 15.4 (ratio) Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells adaptation percent (1 – first/last ISI) 13.4 ± 3.8 (19) 13.4 (ratio) Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells adaptation percent (1 – first/last ISI) 37.3 ± 9.1 (11) 37.3 (ratio) Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells adaptation percent (1 – first/last ISI) 27.3 ± 12.4 (11) 27.3 (ratio) Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike threshold (mV) -41.2 ± 0.9 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike threshold (mV) -43.1 ± 1.0 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike threshold (mV) -44.1 ± 1.2 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike threshold (mV) -43.9 ± 1.3 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike threshold (mV) -38.9 ± 1.1 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike amplitude (mV) 78.1 ± 2.9 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike amplitude (mV) 80.7 ± 2.0 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike amplitude (mV) 79.8 ± 2.2 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike amplitude (mV) 81.9 ± 3.4 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike amplitude (mV) 76.6 ± 2.2 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike half-width (ms) 1.3 ± 0.1 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike half-width (ms) 1.3 ± 0.1 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike half-width (ms) 1.3 ± 0.1 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike half-width (ms) 1.2 ± 0.1 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells spike half-width (ms) 1.7 ± 0.1 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP amplitude (mV) 7.5 ± 1.5 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP amplitude (mV) 5.9 ± 0.9 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP amplitude (mV) 8.1 ± 0.6 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP amplitude (mV) 4.9 ± 0.6 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP amplitude (mV) 7.4 ± 0.9 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells resting membrane potential (mV) -53.0 ± 1.6 (13) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP duration (ms) 253.2 ± 39.9 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP duration (ms) 262.8 ± 31.4 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP duration (ms) 284.5 ± 34.1 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP duration (ms) 292.6 ± 20.8 (11) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells AHP duration (ms) 318.9 ± 31.1 (11) -- Data Table
Other medial septum diagonal band of Broca cluster firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells sag amplitude (mV) 6.4 ± 1.3 (13) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells sag amplitude (mV) 16.1 ± 1.4 (12) -- Data Table
Other medial septum diagonal band of Broca fast firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells sag amplitude (mV) 4.6 ± 0.7 (19) -- Data Table
Other medial septum diagonal band of Broca burst firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells sag amplitude (mV) 3.2 ± 1.1 (11) -- Data Table
Other medial septum diagonal band of Broca fast firing large sag VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells resting membrane potential (mV) -50.3 ± 1.0 (12) -- Data Table
Other medial septum diagonal band of Broca slow firing VGLUT2-expressing neurons projecting to CA3 Hippocampal pyramidal cells sag amplitude (mV) 4.9 ± 1.4 (11) -- Data Table