Input resistance was calculated by R=ΔV/I; with an injected current of −50 pA. Capacitance was calculated by C=τ/R; membrane time constant τ was obtained by a monoexponential fit of the membrane potential shift induced by a current injection of −50 pA. Resting membrane potential was measured immediately after establishing whole-cell configuration. AHP, after-hyperpolarizing potential; measured after the first action potential. Frequency adaptation index calculated by FAI = frequency of the last two APs/frequency of the first two APs. Amplitude adaptation: AA = amplitude of last AP/amplitude of first AP. AP half -width was measured from the first AP.
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Article: Activation of neuropeptide S-expressing neurons in the locus coeruleus by corticotropin-releasing factor.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Jüngling K; Liu X; Lesting J; Coulon P; Sosulina L; Reinscheid RK; Pape HC J. Physiol. (Lond.), 2012
| At −60 mV (n= 47) | |
|---|---|
| Passive | |
| Input resistance (MΩ) | 603 ± 20 |
| Capacitance (pF) | 61 ± 2.6 |
| Membrane time const. (ms) | 36.8 ± 1.9 |
| Resting potential (mV) | −71 ± 1 |
| Active | |
| AP threshold (mV) | −43.6 ± 0.5 |
| Amplitude 1st AP (mV) | 70.1 ± 1 |
| AHP amplitude (mV) | 16 ± 0.5 |
| AP half-width (ms) | 1.4 ± 0.05 |
| Frequency adaptation | 0.6 ± 0.03 |
| Amplitude adaptation | 0.71 ± 0.01 |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Other | Locus coeruleus neuropeptide S expressing neuron | resting membrane potential (mV) | -71.0 ± 1.0 (47) | -71.0 (mV) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | spike threshold (mV) | -43.6 ± 0.5 (47) | -43.6 (mV) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | spike amplitude (mV) | 70.1 ± 1.0 (47) | 70.1 (mV) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | AHP amplitude (mV) | 16.0 ± 0.5 (47) | 16.0 (mV) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | spike half-width (ms) | 1.4 ± 0.05 (47) | 1.4 (ms) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | adaptation ratio | 0.6 ± 0.03 (47) | 0.6 (ratio) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | input resistance (MΩ) | 603.0 ± 20.0 (47) | 603.0 (MΩ) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | cell capacitance (pF) | 61.0 ± 2.6 (47) | 61.0 (pF) | Data Table |
| Other | Locus coeruleus neuropeptide S expressing neuron | membrane time constant (ms) | 36.8 ± 1.9 (47) | 36.8 (ms) | Data Table |