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Article: Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum.

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Ibáñez-Sandoval O; Tecuapetla F; Unal B; Shah F; Koós T; Tepper JM
J. Neurosci., 2010


Table 1.

Electrophysiological properties of striatal EGFP–TH+ interneurons in adult mice

Parameter Type I (84) Type II (18) Type III (8) Type IV (29)
Input resistance (MΩ) 744 ± 33a,b,c (346 to 1500) 429 ± 39 (234 to 758) 180 ± 8f (150 to 205) 471 ± 30 (235 to 821)
n = 78 n = 17 n = 8 n = 29
Resting membrane potential (mV) −71 ± 1a,b,c (−50 to −85) −77 ± 1d (−62 to −82) −89 ± 1 (−86 to −94) −74 ± 1f (−55 to −82)
n = 79 n = 18 n = 8 n = 29
AP threshold (mV) −43 ± 0.3a (−38 to −50) −47 ± 0.5e (−42 to −50) −45 ± 0.6 (−42 to −47) −44 ± 0.5 (−39 to −48)
n = 81 n = 17 n = 8 n = 29
AP width 50% (ms) 0.78 ± 0.03a,b,c (0.4 to 1.9) 0.43 ± 0.01 (0.3 to 0.53) 0.46 ± 0.01 (0.4 to 0.5) 0.5 ± 0.02 (0.4 to 0.85)
n = 81 n = 17 n = 8 n = 29
AP amplitude (mV) 76 ± 1.3a (52 to 101) 94 ± 2d,e (86 to 116) 79 ± 2 (70 to 88) 80 ± 1 (63 to 91)
n = 81 n = 17 n = 8 n = 29
AHP amplitude (mV) 16 ± 0.4a (7 to 24) 20 ± 0.6d,e (16 to 25) 14 ± 0.3 (13 to 16) 15 ± 0.5 (10 to 24)
n = 81 n = 17 n = 8 n = 29
Maximum number of AP (150–200 pA) 7 ± 0.6a,b,c (2 to 22) 53 ± 2d,e (45 to 68) 14 ± 1f (9 to 17) 28 ± 1 (18 to 45)
n = 53 n = 14 n = 8 n = 23
Maximum frequency (Hz) 114 ± 9a,c (32 to 256) 194 ± 10d,e (137 to 265) 98 ± 6f (66 to 124) 321 ± 6 (276 to 386)
n = 53 n = 14 n = 8 n = 23
Spontaneous activity 10 of 84 4 of 18 0 of 8 1 of 29
Plateau potential duration (ms) 255 ± 31 (46 to 1250) 150 ± 116 (15 to 381) 159 ± 41 (119 to 200) 0 of 26
39 of 84 3 of 12 2 of 8
LTS component 0 of 84 4 of 18 0 of 8 29 of 29
Ih ratio 1.12 ± 0.01 (1.03 to 1.54) 1.12 ± 0.02 (1.05 to 1.2) 1.13 ± 0.02 (1.02 to 1.3)
44 of 84 11 of 18 0 of 8 17 of 29
  • All values are means ± SEM. Numbers in parentheses refer to the range of values. n refers to number of neurons from which the measurements were obtained. AP, Action potential; AHP, afterhyperpolarization. One-way ANOVA revealed a significant difference effect of type for all parametric measurements. Bonferroni's post hoc comparisons were run to determine specific type to type differences.

  • aType I versus Type II; bType I versus Type III; cType I versus Type IV; dType II versus Type III; eType II versus Type IV; fType III versus Type IV.

  • a,b,c,d,e,fp < 0.001.

  • a,b,c,d,e,fp < 0.05.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons sag ratio 1.12 ± 0.01 (81) 1.12 (ratio) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons sag ratio 1.12 ± 0.02 (17) 1.12 (ratio) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons sag ratio 1.13 ± 0.02 (29) 1.13 (ratio) Data Table
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons resting membrane potential (mV) -71.0 ± 1.0 (81) -71.0 (mV) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons resting membrane potential (mV) -77.0 ± 1.0 (17) -77.0 (mV) Data Table
Neostriatum TH+ cell Striatum short-bursting tyrosine hydroxylase-expressing neurons resting membrane potential (mV) -89.0 ± 1.0 (8) -89.0 (mV) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons resting membrane potential (mV) -74.0 ± 1.0 (29) -74.0 (mV) Data Table
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons input resistance (MΩ) 744.0 ± 33.0 (29) 744.0 (MΩ) Data Table
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons spike threshold (mV) -43.0 ± 0.3 (29) -43.0 (mV) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons spike threshold (mV) -47.0 ± 0.5 (29) -47.0 (mV) Data Table
Neostriatum TH+ cell Striatum short-bursting tyrosine hydroxylase-expressing neurons spike threshold (mV) -45.0 ± 0.6 (29) -45.0 (mV) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons spike threshold (mV) -44.0 ± 0.5 (29) -44.0 (mV) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons input resistance (MΩ) 429.0 ± 39.0 (29) 429.0 (MΩ) Data Table
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons spike half-width (ms) 0.78 ± 0.03 (81) 0.78 (ms) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons spike half-width (ms) 0.43 ± 0.01 (17) 0.43 (ms) Data Table
Neostriatum TH+ cell Striatum short-bursting tyrosine hydroxylase-expressing neurons spike half-width (ms) 0.46 ± 0.01 (17) 0.46 (ms) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons spike half-width (ms) 0.5 ± 0.02 (29) 0.5 (ms) Data Table
Neostriatum TH+ cell Striatum short-bursting tyrosine hydroxylase-expressing neurons input resistance (MΩ) 180.0 ± 8.0 (29) 180.0 (MΩ) Data Table
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons spike amplitude (mV) 76.0 ± 1.3 (81) 76.0 (mV) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons spike amplitude (mV) 94.0 ± 2.0 (81) 94.0 (mV) Data Table
Neostriatum TH+ cell Striatum short-bursting tyrosine hydroxylase-expressing neurons spike amplitude (mV) 79.0 ± 2.0 (81) 79.0 (mV) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons spike amplitude (mV) 80.0 ± 1.0 (29) 80.0 (mV) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons input resistance (MΩ) 471.0 ± 30.0 (29) 471.0 (MΩ) Data Table
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons AHP amplitude (mV) 16.0 ± 0.4 (81) 16.0 (mV) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons AHP amplitude (mV) 20.0 ± 0.6 (17) 20.0 (mV) Data Table
Neostriatum TH+ cell Striatum short-bursting tyrosine hydroxylase-expressing neurons AHP amplitude (mV) 14.0 ± 0.3 (8) 14.0 (mV) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons AHP amplitude (mV) 15.0 ± 0.5 (29) 15.0 (mV) Data Table
Neostriatum TH+ cell Striatum irregular-bursting tyrosine hydroxylase-expressing neurons maximum firing rate (Hz) 114.0 ± 9.0 (81) 114.0 (Hz) Data Table
Neostriatum TH+ cell Striatum fast-spiking tyrosine hydroxylase-expressing neurons maximum firing rate (Hz) 194.0 ± 10.0 (17) 194.0 (Hz) Data Table
Neostriatum TH+ cell Striatum short-bursting tyrosine hydroxylase-expressing neurons maximum firing rate (Hz) 98.0 ± 6.0 (8) 98.0 (Hz) Data Table
Neostriatum TH+ cell Striatum low-threshold spiking tyrosine hydroxylase-expressing neurons maximum firing rate (Hz) 321.0 ± 6.0 (29) 321.0 (Hz) Data Table