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Article: Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons.

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Elbasiouny SM; Amendola J; Durand J; Heckman CJ
J. Neurosci., 2010


Table 1.

Experimental data on electrical properties of mSOD1 motoneurons

Property WT mSOD1
Input resistance; Rin (MΩ) 16.2 ± 4.78 (34) 11.4 ± 2.96*** (23)
Resting potential; Vrest (mV) −70.03 ± 7.16 (34) −69.61 ± 6.16 (23)
Time constant; τ0 (ms) 11.05 ± 2.64 (11) 14.4 ± 6.25 (7)
Cell capacitance; Ct (pF) 727 ± 253 (11) 1404 ± 1055 (7)
  • Experimental data were recorded from neonatal (P8–P10) WT and mSOD1 motoneurons in the whole-cord preparation (2 mm extracellular Ca2+ concentration). Data are expressed as mean ± SD.

  • ***High statistical significance (p = 0.00002 for unpaired t test and 0.00006 for the Mann–Whitney U test). Values in parentheses indicate number of cells in each group. These data include those of the reconstructed motoneurons. Same data as in Figure 1B, right.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha cell capacitance (pF) 727.0 ± 253.0 (11) 727.0 (pF) Data Table
Spinal cord ventral horn motor neuron alpha input resistance (MΩ) 16.2 ± 4.78 (34) 16.2 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha resting membrane potential (mV) -70.03 ± 7.16 (34) -70.03 (mV) Data Table
Spinal cord ventral horn motor neuron alpha membrane time constant (ms) 11.05 ± 2.64 (11) -- Data Table