Article: Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Mu P; Moyer JT; Ishikawa M; Zhang Y; Panksepp J; Sorg BA; Schlüter OM; Dong Y J. Neurosci., 2010
Treatment | Saline w/d | Cocaine w/d | Saline w/d + cocaine | Cocaine w/d + cocaine | Acute cocaine |
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Number of cells | n = 16 | n = 14 | n = 17 | n = 16 | n = 9 |
Break-in RMP (mV) | −75.2 ± 0.9 | −76.5 ± 0.7 | −75.1 ± 0.8 | −73.3 ± 0.9 | −75.1 ± 0.7 |
Stabilized RMP (mV) | −82.5 ± 0.8 | −83.5 ± 0.6 | −81.5 ± 0.7 | −80.7 ± 0.5 | −81.9 ± 0.9 |
Ri at −100 pA (MΩ) | 124.9 ± 6.8 | 101.1 ± 5.7 | 109.8 ± 4.7 | 129.3 ± 4.1 | 107.4 ± 5.7 |
Ri at +100 pA (MΩ) | 240.4 ± 7.3 | 227.4 ± 8.8 | 211.9 ± 7.6 | 248.2 ± 7.1 | 222.1 ± 4.9 |
Latency, 1st spike (ms) | 176 ± 12 | 175 ± 16 | 183 ± 16 | 186 ± 13 | 178 ± 11 |
Rheobase (pA) | 133 ± 11 (n = 11) | 114 ± 12 (n = 7) | 135 ± 12 (n = 7) | 110 ± 16 (n = 5) | 121 ± 13 (n = 4) |
AP threshold (mV) | −30.7 ± 0.8 | −30.9 ± 1.1 | −31.2 ± 0.7 | −29.9 ± 0.6 | −31.1 ± 0.8 |
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RMP, Resting membrane potential; Ri, input resistance; AP, action potential; Rheobase, minimal current that elicits an action potential along the duration (300 ms) of the test step.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Nucleus accumbens shell neuron | resting membrane potential (mV) | -82.5 ± 0.8 | -82.5 (mV) | Data Table | |
Nucleus accumbens shell neuron | first spike latency (ms) | 176.0 ± 12.0 | 176.0 (ms) | Data Table | |
Nucleus accumbens shell neuron | rheobase (pA) | 133.0 ± 11.0 | 133.0 (pA) | Data Table | |
Nucleus accumbens shell neuron | spike threshold (mV) | -30.7 ± 0.8 | -30.7 (mV) | Data Table |