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Article: Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons.

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Mu P; Moyer JT; Ishikawa M; Zhang Y; Panksepp J; Sorg BA; Schlüter OM; Dong Y
J. Neurosci., 2010


Table 3.

Membrane properties: 3 week withdrawal from SA administration

Treatment Saline w/d Cocaine w/d Saline w/d + cocaine Cocaine w/d + cocaine Acute cocaine
Number of cells n = 16 n = 14 n = 17 n = 16 n = 9
Break-in RMP (mV) −75.2 ± 0.9 −76.5 ± 0.7 −75.1 ± 0.8 −73.3 ± 0.9 −75.1 ± 0.7
Stabilized RMP (mV) −82.5 ± 0.8 −83.5 ± 0.6 −81.5 ± 0.7 −80.7 ± 0.5 −81.9 ± 0.9
Ri at −100 pA (MΩ) 124.9 ± 6.8 101.1 ± 5.7 109.8 ± 4.7 129.3 ± 4.1 107.4 ± 5.7
Ri at +100 pA (MΩ) 240.4 ± 7.3 227.4 ± 8.8 211.9 ± 7.6 248.2 ± 7.1 222.1 ± 4.9
Latency, 1st spike (ms) 176 ± 12 175 ± 16 183 ± 16 186 ± 13 178 ± 11
Rheobase (pA) 133 ± 11 (n = 11) 114 ± 12 (n = 7) 135 ± 12 (n = 7) 110 ± 16 (n = 5) 121 ± 13 (n = 4)
AP threshold (mV) −30.7 ± 0.8 −30.9 ± 1.1 −31.2 ± 0.7 −29.9 ± 0.6 −31.1 ± 0.8
  • RMP, Resting membrane potential; Ri, input resistance; AP, action potential; Rheobase, minimal current that elicits an action potential along the duration (300 ms) of the test step.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens shell neuron resting membrane potential (mV) -82.5 ± 0.8 -82.5 (mV) Data Table
Nucleus accumbens shell neuron first spike latency (ms) 176.0 ± 12.0 176.0 (ms) Data Table
Nucleus accumbens shell neuron rheobase (pA) 133.0 ± 11.0 133.0 (pA) Data Table
Nucleus accumbens shell neuron spike threshold (mV) -30.7 ± 0.8 -30.7 (mV) Data Table