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Article: Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease.

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Cummings DM; André VM; Uzgil BO; Gee SM; Fisher YE; Cepeda C; Levine MS
J. Neurosci., 2009


Table 1.

Basic membrane properties pyramidal neurons in slices from R6/2 mice

21 d (CsMeth) 40 d (CsMeth) 80 d (CsMeth) 80 d (KGluc)
WT (n = 35) R6/2 (n = 44) WT (n = 19) R6/2 (n = 21) WT (n = 28) R6/2 (n = 35) WT (n = 11) R6/2 (n = 12)
Rm (MΩ) 110 ± 5 104 ± 6 131 ± 13 133 ± 12 173 ± 10 178 ± 10 135 ± 23 221 ± 16**
τ (ms) 2.7 ± 0.1 2.9 ± 0.1 2.6 ± 0.2 2.5 ± 0.2 2.1 ± 0.2 2.0 ± 0.1 2.2 ± 0.2 1.8 ± 0.2
Cm (pF) 150 ± 7 146 ± 5 122 ± 7 129 ± 6 107 ± 6 101 ± 4 145 ± 13 99 ± 6**
RMP (mV) −73.1 ± 1.6 −65.3 ± 2.9*
APthreshold (mV) −44.1 ± 1.7 −45.5 ± 3.8
  • In each column, data for WT and R6/2 are presented at the ages indicated. Internal solution and n values are indicated in parentheses. Significance is indicated by *p < 0.05; **p < 0.01. APthreshold, Action potential threshold.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 membrane time constant (ms) 2.7 ± 0.1 (35) 2.7 (ms) Data Table
Neocortex pyramidal cell layer 2-3 membrane time constant (ms) 2.6 ± 0.2 (19) 2.6 (ms) Data Table
Neocortex pyramidal cell layer 2-3 membrane time constant (ms) 2.1 ± 0.2 (28) 2.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 membrane time constant (ms) 2.2 ± 0.2 (11) 2.2 (ms) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 110.0 ± 5.0 (35) 110.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 cell capacitance (pF) 150.0 ± 7.0 (35) 150.0 (pF) Data Table
Neocortex pyramidal cell layer 2-3 cell capacitance (pF) 122.0 ± 7.0 (19) 122.0 (pF) Data Table
Neocortex pyramidal cell layer 2-3 cell capacitance (pF) 107.0 ± 6.0 (28) 107.0 (pF) Data Table
Neocortex pyramidal cell layer 2-3 cell capacitance (pF) 145.0 ± 13.0 (11) 145.0 (pF) Data Table
Neocortex pyramidal cell layer 2-3 resting membrane potential (mV) -73.1 ± 1.6 (11) -73.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 131.0 ± 13.0 (19) 131.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 spike threshold (mV) -44.1 ± 1.7 (11) -44.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 173.0 ± 10.0 (28) 173.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 135.0 ± 23.0 (11) 135.0 (MΩ) Data Table