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Article: Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs.

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Plotkin JL; Wu N; Chesselet MF; Levine MS
Eur. J. Neurosci., 2005


Table 1.  Membrane properties of FS interneurons and MS neurons
 UnitsFSMS
P12–14 (n = 10)FS P19–23 (n = 11)P12–14 (n = 12)MS P19–23 (n = 9–11)

  1. All AP properties were measured from the first AP in a train resulting from a depolarizing current injection of threshold strength for APs. The frequency was measured as the maximum frequency at which the cell fired before failures were observed, in response to a 100-ms pulse. *P < 0.05 vs. FS P12–14;**P < 0.01 vs. FS P12–14; ##P < 0.01 vs. MS P12–14. Significance was determined with t-tests. For MS P19–23 n = 11 for all properties except input resistance (n = 9).

Input resistanceMΩ117.42 ± 10.1291.76 ± 5.89*120.47 ± 6.2392.41 ± 8.84##
AP frequencyHz133 ± 12.02284.54 ± 13.24**39.17 ± 3.1352.73 ± 3.33##
AP threshold current injectionpA200 ± 21.08236.36 ± 62.19175 ± 25200 ± 33.03
Amplitude of APmV62.23 ± 3.4674.03 ± 2.77*79.43 ± 2.3295.56 ± 3.34##
AP width at 1/2 amplitudems0.91 ± 0.060.58 ± 0.02**1.7 ± 0.061.55 ± 0.16
Amplitude of AHPmV11.81 ± 1.835.18 ± 1.42**6.38 ± 0.525.99 ± 1.22
Time to peak of AHPms3.11 ± 0.311.6 ± 0.04**9.66 ± 0.7312.35 ± 1.84

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron firing frequency 133.0 ± 12.02 (10) 133.0 (Hz) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron firing frequency 284.54 ± 13.24 (11) 284.54 (Hz) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons firing frequency 39.17 ± 3.13 (12) 39.17 (Hz) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons firing frequency 52.73 ± 3.33 (10) 52.73 (Hz) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron rheobase 200.0 ± 21.08 (10) 200.0 (pA) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron rheobase 236.36 ± 62.19 (11) 236.36 (pA) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons rheobase 175.0 ± 25.0 (12) 175.0 (pA) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons rheobase 200.0 ± 33.03 (10) 200.0 (pA) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron spike amplitude 62.23 ± 3.46 (10) 62.23 (mV) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron spike amplitude 74.03 ± 2.77 (11) 74.03 (mV) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons spike amplitude 79.43 ± 2.32 (12) 79.43 (mV) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons spike amplitude 95.56 ± 3.34 (10) 95.56 (mV) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron spike half-width (at) 0.91 ± 0.06 (10) -- Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron spike half-width (at) 0.58 ± 0.02 (11) -- Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons spike half-width (at) 1.7 ± 0.06 (12) -- Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons spike half-width (at) 1.55 ± 0.16 (10) -- Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron AHP amplitude 11.81 ± 1.8 (10) 11.81 (mV) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron AHP amplitude 35.18 ± 1.42 (11) 35.18 (mV) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons AHP amplitude 6.38 ± 0.52 (12) 6.38 (mV) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons AHP amplitude 5.99 ± 1.22 (10) 5.99 (mV) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron input resistance 117.42 ± 10.12 (10) 117.42 (MΩ) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron AHP duration 3.11 ± 0.31 (10) 3.11 (ms) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron AHP duration 1.6 ± 0.04 (11) 1.6 (ms) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons AHP duration 9.66 ± 0.73 (12) 9.66 (ms) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons AHP duration 12.35 ± 1.84 (10) 12.35 (ms) Data Table
Neostriatum gabaergic interneuron Neostraitum fast-spiking gabaergic interneuron input resistance 91.76 ± 5.89 (11) 91.76 (MΩ) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons input resistance 120.47 ± 6.23 (12) 120.47 (MΩ) Data Table
Neostriatum medium spiny neuron Neostriatum medium-sized spiny projection neurons input resistance 92.41 ± 8.84 (10) 92.41 (MΩ) Data Table