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Article: Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Trantham H; Szumlinski KK; McFarland K; Kalivas PW; Lavin A Neuroscience, 2002
Table 1Basic electrophysiological characteristics of PFC neurons
Data are shown as mean±S.D.aStudent’s t-test, P<0.0003, comparing with duration of the Up state.bStudent’s t-test, P<0.02, comparing with control bistable.cFisher exact test, P<0.05, comparing with control bistable.
| Control (n=9) | Control bistable (n=6) | Cocaine (n=17) | |
| Resting MP (mV) | −66.7±7.3 (58.4–81.9) | −70.0±10.5 (51.2–85.6) | |
| MP Up state (mV) | −57.4±6.0 (51.6–64.5) | ||
| MP Down state (mV) | −76.0±4.7 (70.5–83.1) | ||
| Duration Up state (ms) | 369.3±1144.8 (100–792) | ||
| Duration Down state (ms) | 1368±1605a(155–4751) | ||
| Spike threshold (mV) | −49.1±6.5 (49.8–60.2) | −54.1±2.4 (51.4–58.3) | −52.7±4.4 (44.2–61.4) |
| Spike amplitude (mV) | 55.2±7.3 (49–65.4) | 61.1±8.7 (53.4–70.6) | 50.9±6.8 (49.3–68.3) |
| Input resistance (MΩ) | 61.3±22.0 (30–89) | 41.5±22.5 (21–79) | 73.3±27.3 (37.3–129)b |
| Firing frequency (Hz) | 4.6±8.9 (0–27.8) | 7.0±7.4 (1.6–20.9) | 3.6±5.4 (0–24.1) |
| Bistability | 6/15 (40%) | 0/17 (0.0%)c |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 5-6 | Prefrontal Cortex Layer 5-6 Pyramidal Neurons | spike threshold (mV) | -49.1 ± 6.5 (9) | -49.1 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal Cortex Layer 5-6 Pyramidal Neurons | spike amplitude from resting (mV) | 55.2 ± 7.3 (9) | 55.2 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal Cortex Layer 5-6 Pyramidal Neurons | input resistance (MΩ) | 61.3 ± 22.0 (9) | 61.3 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal Cortex Layer 5-6 Pyramidal Neurons | firing frequency (Hz) | 4.6 ± 8.9 (9) | 4.6 (Hz) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal Cortex Layer 5-6 Pyramidal Neurons | resting membrane potential (mV) | -66.7 ± 7.3 (9) | -66.7 (mV) | Data Table |