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Article: Histaminergic effects on the frequency of repetitive spike firing in rat insular cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Takei H; Song L; Ebihara K; Shirakawa T; Koshikawa N; Kobayashi M Neurosci. Lett., 2012
Table 1Effects of histaminergic agonists and antagonists on the intrinsic electrophysiological properties of pyramidal cells.
aResting membrane potential.*P<0.05.***P<0.001 (Student's t-test).
| Vma (mV) | Input resistance (MΩ) | Rheobase (nA) | f/I slope (Hz/nA) | |||||
| Mean±S.E.M. | n | Mean±S.E.M. | n | Mean±S.E.M. | n | Mean±S.E.M. | n | |
| Control | −75.5±2.1 | 14 | 33.4±2.8 | 16 | 0.64±0.08 | 16 | 23.3±2.3 | 14 |
| +Histamine (30μM) | −72.9±2.0 | 39.4±3.8*** | 0.50±0.07 | 40.3±4.3* | ||||
| Pyrilamine (30μM) | −69.9±3.5 | 10 | 26.3±2.0 | 9 | 0.63±0.06 | 7 | 22.7±4.8 | 8 |
| +Histamine (30μM) | −68.2±3.2 | 28.5±2.7 | 0.51±0.08 | 30.4±3.4* | ||||
| Cimetidine (50 μM) | −74.6 ± 2.7 | 19 | 25.5 ± 2.2 | 12 | 0.80 ± 0.08 | 22 | 17.2 ± 2.3 | 16 |
| +Histamine (30μM) | −74.4±2.6 | 27.7±2.5 | 0.80±0.08 | 20.6±2.6 | ||||
| Control | −68.2±1.8 | 14 | 35.9±2.5 | 14 | 0.52±0.07 | 14 | 21.3±4.0 | 8 |
| +RAMH (10μM) | −65.1±1.9 | 36.9±2.8 | 0.45±0.04 | 25.2±5.1 | ||||
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Other | Insular Cortex Pyramidal Neurons | resting membrane potential (mV) | -75.5 ± 2.1 (16) | -75.5 (mV) | Data Table |
| Other | Insular Cortex Pyramidal Neurons | input resistance (MΩ) | 33.4 ± 2.8 (16) | 33.4 (MΩ) | Data Table |
| Other | Insular Cortex Pyramidal Neurons | rheobase (nA) | 0.64 ± 0.08 (16) | 640.0 (pA) | Data Table |
| Other | Insular Cortex Pyramidal Neurons | FI slope (Hz/nA) | 23.3 ± 2.3 (16) | 23.3 (Hz/nA) | Data Table |