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Article: Altered intrinsic properties of neuronal subtypes in malformed epileptogenic cortex.

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George AL; Jacobs KM
Brain Res., 2011


Table 2Intrinsic properties of layer V interneurons and pyramidal cells.
Electrophysiological parameterFSLTSPyr
ControlControlControl
PMGPMGPMG
Resting membrane potential, mV−62.7±6.3 (31)−55.4±4.2 (31)−56.2±5.3 (28)
−63.0±7.3 (24)−58.7±5.2 (19)**−57.3±8.2 (22)
Input resistance, MΩ120±7 (32)191±16 (32)121±16 (29)
123±7 (25)173±22 (21)140±18 (21)
Spike amplitude, mV81.8±1.1 (34)99.2±1.4 (33)103.6±0.8 (28)
85.3±1.3 (30)**96.3±1.7 (23)102.4±1.0 (16)
Max rate of rise, V/s256±12 (34)244±13 (33)287±11 (28)
253±13 (30)239±11 (23)272±13 (16)
Max rate of decay, V/s117±7 (34)85±4 (33)42±2 (28)
115±9 (30)84±5 (23)39±2 (16)
dV/dt ratio2.3±0.1 (34)2.9±0.1 (33)6.9±0.2 (28)
2.4±0.1 (30)2.9±0.1 (23)7.1±0.3 (16)
Primary F/I slope (Hz/nA)407±25 (34)471±33 (33)87±18 (28)
400±23 (30)481±41 (23)97±20 (16)
All data are expressed as means±SE (n cells). Student's t-test was used to compare control and PMG values within each group, ** indicates p<0.05.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron resting membrane potential (mV) -62.7 ± 6.3 (31) -62.7 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron resting membrane potential (mV) -55.4 ± 4.2 (31) -55.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell resting membrane potential (mV) -56.2 ± 5.3 (28) -56.2 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron input resistance (MΩ) 120.0 ± 7.0 (32) 120.0 (MΩ) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron input resistance (MΩ) 191.0 ± 16.0 (32) 191.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell input resistance (MΩ) 121.0 ± 16.0 (29) 121.0 (MΩ) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron spike amplitude (mV) 81.8 ± 1.1 (34) 81.8 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron spike amplitude (mV) 99.2 ± 1.4 (33) 99.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell spike amplitude (mV) 103.6 ± 0.8 (28) 103.6 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron spike max rise slope (V/s) 256.0 ± 12.0 (34) 256.0 (mV/ms) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron spike max rise slope (V/s) 244.0 ± 13.0 (33) 244.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell spike max rise slope (V/s) 287.0 ± 11.0 (28) 287.0 (mV/ms) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron spike max decay slope (V/s) 117.0 ± 7.0 (34) 117.0 (mV/ms) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron spike max decay slope (V/s) 85.0 ± 4.0 (33) 85.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell spike max decay slope (V/s) 42.0 ± 2.0 (28) 42.0 (mV/ms) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron FI slope (Hz/nA) 407.0 ± 25.0 (34) 407.0 (Hz/nA) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron FI slope (Hz/nA) 471.0 ± 33.0 (33) 471.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell FI slope (Hz/nA) 87.0 ± 18.0 (28) 87.0 (Hz/nA) Data Table