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Article: Electrophysiological characteristics of substantia nigra neurons in organotypic cultures: spontaneous and evoked activities.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Rohrbacher J; Ichinohe N; Kitai ST Neuroscience, 2000
Table 1Electrophysiological characteristics of dopaminergic and non-dopaminergic neuronsa
aData are given as mean±S.E.M.; in bracket the number of cells are indicated. AP, action potential; the duration of action potentials was measured at threshold. AHP, afterhyperpolarization; the amplitude of the AHP was measured from threshold of the action potential to the peak. The time to peak of AHP was measured from the peak of the action potential to the peak of the AHP. Ih, time-dependent inward rectification measured as the ratio of membrane deflection at the end and the peak of a hyperpolarizing current pulse (duration 300 ms, 0.3–0.5 nA). Firing frequency adaptation, the ratio between the last interspike interval and the first interspike interval at given depolarizing current pulses (0.35–0.7 nA, duration 300 ms). Slope, relationship between overall spike frequency and injected current.b**P<0.01; *P<0.05.
| DA neurons | Non-DA neurons | |
| Input resistance (MΩ) | 140.0±20.1 (7) | 126.9±10.4 (23) |
| AP threshold (mV) | −45.0±1.0* (7) | −49.2±0.7 (23) |
| AP amplitude (mV) | 49.1±1.8 (7) | 45.0±1.9 (23) |
| AP duration (ms) | 2.5±0.2** (7) | 1.5±0.2 (23) |
| Ih | 0.77±0.04** (8) | 0.96±0.01 (30) |
| AHPslow amplitude (mV) | −19.9±1.2** (5) | −11.6±0.8 (11) |
| AHPslow time (ms) | 17.6±2.8 (5) | 15.0±1.6 (11) |
| Firing frequency adaptation | 0.32±0.07* (7) | 0.56±0.06 (16) |
| Slope (Hz/nA) | 36.3±5.4** (7) | 128.0±11.3 (23) |
| Firing frequency (Hz) (0.8 nA) | 39.9±5.8 (7)** | 76.6±7.5 (14) |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | spike amplitude (mV) | 49.1 ± 1.8 | 49.1 (mV) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | spike amplitude (mV) | 45.0 ± 1.9 | 45.0 (mV) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | spike width (ms) | 2.5 ± 0.2 | 2.5 (ms) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | spike width (ms) | 1.5 ± 0.2 | 1.5 (ms) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | slow AHP amplitude (mV) | -19.9 ± 1.2 | 19.9 (mV) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | slow AHP amplitude (mV) | -11.6 ± 0.8 | 11.6 (mV) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | slow AHP duration (ms) | 17.6 ± 2.8 | 17.6 (ms) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | slow AHP duration (ms) | 15.0 ± 1.6 | 15.0 (ms) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | adaptation ratio | 0.32 ± 0.07 | 0.32 (ratio) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | adaptation ratio | 0.56 ± 0.06 | 0.56 (ratio) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | FI slope (Hz/nA) | 36.3 ± 5.4 | 36.3 (Hz/nA) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | FI slope (Hz/nA) | 128.0 ± 11.3 | 128.0 (Hz/nA) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | firing frequency | 39.9 ± 5.8 | 39.9 (Hz) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | firing frequency | 76.6 ± 7.5 | 76.6 (Hz) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | input resistance (MΩ) | 140.0 ± 20.1 | 140.0 (MΩ) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | input resistance (MΩ) | 126.9 ± 10.4 | 126.9 (MΩ) | Data Table |
| Substantia nigra pars compacta dopaminergic cell | Substantia nigra pars compacta long duration action potential dopaminergic neuron | spike threshold (mV) | -45.0 ± 1.0 | -45.0 (mV) | Data Table |
| Substantia nigra pars reticulata interneuron GABA | Substantia nigra pars reticulata rapidly firing short duration action potential GABAergic neuron | spike threshold (mV) | -49.2 ± 0.7 | -49.2 (mV) | Data Table |