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Article: Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures.

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Polack PO; Guillemain I; Hu E; Deransart C; Depaulis A; Charpier S
J. Neurosci., 2007


Table 1.

Intrinsic membrane properties of neurons recorded from GAERS and normal Wistar rats

Membrane resistance (MΩ) Time constant (ms) Action potential amplitude (mV) Action potential duration (ms) Action potential threshold (mV)
GAERS
    Focus Layer 2/3 27.5 ± 3.7 9.9 ± 2.5 56.5 ± 2.9 1.7 ± 0.1 −50.6 ± 1.3
Layer 4 43.4 ± 3.2 1 14.2 ± 2.0 53.8 ± 4.9 1.8 ± 0.1 −52.0 ± 2.8
Layer 5/6 21.7 ± 2.2 1 7.9 ± 0.9 57.8 ± 2.3 1.6 ± 0.1 −53.6 ± 0.6
    MoCx Layer 5/6 25.8 ± 3.6 1 14.0 ± 2.5 60.4 ± 1.8 1.6 ± 0.1 −53.2 ± 0.9
Wistar
    SoCx Layer 5/6 30.0 ± 4.1 6.5 ± 0.9 56.7 ± 1.1 1.8 ± 0.2 −52.8 ± 1.2
  • Electrical parameters were measured in GAERS neurons, located in layer 2/3 (n = 6), layer 4 (n = 5), and layer 5/6 (n = 17) of the cortical focus and in layer 5/6 of motor cortex (MoCx; n = 9) and in nonepileptic Wistar rat somatosensory cortical neurons (SoCx; n = 7). All parameters were not significantly different (p > 0.05), except the membrane resistance of GAERS focus layer 4 neurons that was significantly higher than that of focus and motor cortex layer 5/6 cells (p < 0.001).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5/6 pyramidal neurons input resistance (MΩ) 30.0 ± 4.1 (7) 30.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5/6 pyramidal neurons membrane time constant (ms) 6.5 ± 0.9 (7) 6.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5/6 pyramidal neurons spike amplitude (mV) 56.7 ± 1.1 (7) 56.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5/6 pyramidal neurons spike width (ms) 1.8 ± 0.2 (7) 1.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5/6 pyramidal neurons spike threshold (mV) -52.8 ± 1.2 (7) -52.8 (mV) Data Table