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Article: Sensory experience alters cortical connectivity and synaptic function site specifically.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Cheetham CE; Hammond MS; Edwards CE; Finnerty GT J. Neurosci., 2007
Effects of sensory deprivation on layer 2/3 pyramidal neurons
| Control | Deprived | Spared | |
|---|---|---|---|
| Age (postnatal days) | 42 (36–48) | 41 (37–45) | 45 (35–46) |
| Trim duration (days) | 23 (17–29) | 22 (18–26) | 26 (16–27) |
| Presynaptic resting membrane potential (mV) | −76 (−78 to −72) | −75 (−79 to −74) | −73 (−78 to −70) |
| Postsynaptic resting membrane potential (mV) | −76 ± 1 | −77 ± 1 | −77 ± 1 |
| Postsynaptic input resistance (MΩ) | 59 ± 3 | 51 ± 4 | 57 ± 4 |
| Postsynaptic membrane time constant (ms) | 14.1 ± 0.7 | 12.3 ± 1.4 | 14.5 ± 0.6 |
| Rheobase (pA) | 300 (250–360) | 250 (210–300) | 280 (210–400) |
| Input–output slope in Figure 1E (action potentials per nA) ×10−2 | 6.8 ± 0.3 | 6.5 ± 0.3 | 6.1 ± 0.3 |
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Age, trim duration, and passive membrane properties are from recordings of pairs of synaptically connected pyramidal neurons. Normally distributed data are reported as mean ± SEM. Non-normal data are given as median (interquartile range). One-way ANOVA showed no difference in postsynaptic resting membrane potential (p = 0.43; F(2,60) = 0.86; n = 63), postsynaptic input resistance (p = 0.58; F(2,58) = 0.54; n = 61), postsynaptic membrane time constant (p = 0.31; F(2,57) = 1.19; n = 60), or input–output slope (p = 0.22; F(2, 95) = 1.53; n = 98). One-way ANOVA on ranks revealed no difference in age (p = 0.95; H = 0.10; df = 2; n = 61), trim duration (p = 0.95; H = 0.10; df = 2; n = 61), presynaptic resting membrane potential (p = 0.36; H = 2.04; df = 2; n = 63), or rheobase (p = 0.54; H = 1.24; df = 2; n = 93).
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 2-3 | resting membrane potential (mV) | -76.0 ± 1.0 | -76.0 (mV) | Data Table | |
| Neocortex pyramidal cell layer 2-3 | input resistance (MΩ) | 59.0 ± 3.0 | 59.0 (MΩ) | Data Table | |
| Neocortex pyramidal cell layer 2-3 | membrane time constant (ms) | 14.1 ± 0.7 | 14.1 (ms) | Data Table | |
| Neocortex pyramidal cell layer 2-3 | rheobase (pA) | 300.0 | 300.0 (pA) | Data Table |