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Article: Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.

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Zhan RZ; Nadler JV
J. Neurophysiol., 2009


TABLE 2.

Effects of subtype-selective GABAA receptor ligands on frequency and properties of sIPSCs in dentate granule cells

CGC GC-SE HEGC
Before + Ligand Before + Ligand Before + Ligand
THDOC
    Frequency, Hz 3.1 ± 0.6 3.8 ± 0.4 3.1 ± 0.7 3.0 ± 0.9 1.1 ± 0.3 1.6 ± 0.7
    Amplitude, pA 30.3 ± 4.0 29.1 ± 2.5 27.6 ± 3.5 23.4 ± 4.2 22.8 ± 4.9 25.0 ± 3.1
    10–90% rise time, ms 1.7 ± 0.3 2.0 ± 0.2 2.4 ± 0.2 2.4 ± 0.3 2.8 ± 0.9 2.3 ± 0.4
    τ, ms 10.6 ± 0.9 13.3 ± 3.2 10.2 ± 0.8 9.6 ± 1.6 10.8 ± 2.8 10.9 ± 3.1
    Charge transfer, fC 301 ± 52 354 ± 44 265 ± 39 221 ± 58 293 ± 88 214 ± 40
L-655708
    Frequency, Hz 2.5 ± 0.3 2.2 ± 0.4 2.4 ± 0.9 2.2 ± 0.8 3.0 ± 0.6 2.3 ± 0.5
    Amplitude, pA 28.4 ± 3.8 25.7 ± 3.1 27.0 ± 3.6 21.2 ± 5.6 37.5 ± 8.6 25.7 ± 6.6
    10–90% rise time, ms 2.8 ± 0.9 2.3 ± 0.4 1.9 ± 0.2 2.1 ± 0.1 1.8 ± 0.2 2.0 ± 0.3
    τ, ms 9.5 ± 0.3 7.8 ± 0.4 10.9 ± 0.6 9.0 ± 0.9 12.3 ± 1.5 8.0 ± 1.3
    Charge transfer, fC 234 ± 29 175 ± 20 293 ± 46 192 ± 56* 426 ± 95 191 ± 52
  • Values are means ± SE for 5 (CGC/THDOC), 6 (CGC/L-655,708), 6 (GC-SE/THDOC), 7 (GC-SE/L-655,708), 6 (HEGC/THDOC), or 7 (HEGC/L-655,708) cells per group. The number of sIPSCs recorded during a 2.5-min period and the properties of averaged sIPSCs were determined before and during exposure to the test compound at 22–24°C. Where indicated, the ligand altered the sIPSC property significantly at

  • * P < 0.05.

  • P < 0.02, or

  • P < 0.01 (paired t-test). sIPSC, spontaneous inhibitory postsynaptic current. See Table 1 for other abbreviations.


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