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Article: Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats.

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Yoshimura N; Bennett NE; Hayashi Y; Ogawa T; Nishizawa O; Chancellor MB; de Groat WC; Seki S
J. Neurosci., 2006


Table 3.

K+ and Na+ current characteristics of bladder afferent neurons with TTX-resistant spikes from vehicle-treated and NGF-treated rats

Vehicle NGF (2 weeks)
K+ currents
    No. of cells 15 20
    Input capacitance (pF) 30.8 ± 1.7 42.5 ± 2.7**
    KA conductance (at 0 mV)
        Max (nS) 33.6 ± 4.4 21.9 ± 2.8*
        Normalized (nS/pF) 1.09 ± 0.16 0.52 ± 0.07**
    KDR conductance (at 20 mV)
        Max (nS) 39.9 ± 3.8 49.9 ± 3.3
        Normalized (nS/pF) 1.33 ± 0.13 1.19 ± 0.09
Na+ currents
    No. of cells 15 20
    Input capacitance (pF) 30.1 ± 1.6 43.1 ± 2.6**
    TTX-R Na+ conductance (at 10 mV)
        Max (nS) 69.5 ± 3.6 97.4 ± 3.9*
        Normalized (nS/pF) 2.31 ± 0.12 2.26 ± 0.11
    TTX-S Na+ conductance (at 10 mV)
        Max (nS) 42.3 ± 4.1 53.1 ± 3.5
        Normalized (nS/pF) 1.41 ± 0.13 1.23 ± 0.10

  • Max, Maximal conductance. Normalized, Conductance normalized with respect to cell input capacitance.

  • ↵*p < 0.05,

  • ↵**p < 0.01 compared with the value in bladder afferent neurons with TTX-resistant spikes from vehicle-treated rats.


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