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Article: Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.

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Kumar SS; Buckmaster PS
J. Neurosci., 2006


Table 2.

Intrinsic electrophysiological properties of interneurons and pyramidal cells in layer III of the medial entorhinal cortex in control and epileptic rats

Type I interneuron Type II interneuron Layer III pyramidal cell Significant differences
Resting membrane potential (mV) −64 ± 1.3 −54 ± 1.1 −55 ± 1.5 II = Pyr > I
(n = 28) (n = 25) (n = 9)
Membrane resistance (MΩ) 143 ± 11 382 ± 47 49 ± 3 II > I = Pyr
(n = 28) (n = 25) (n = 5)
Membrane capacitance (pF) 51 ± 3 51 ± 1 130 ± 9 Pyr > I = II
(n = 28) (n = 25) (n = 5)
Action potential half-width (ms) 0.2 ± 0.01 0.4 ± 0.01 0.5 ± 0.04 Pyr = II > I
(n = 11) (n = 11) (n = 9)
Spike afterhyperpolarization amplitude (mV) 31 ± 1.3 38 ± 1.5 7 ± 0.4 II > I > Pyr
(n = 11) (n = 11) (n = 9)
  • Values are mean ± SEM. ANOVA revealed significant differences between neuron types for every property (p < 0.0001). Post hoc Bonferroni's-adjusted t test showed significant differences (p < 0.05) as indicated between type I interneurons (I), type II interneurons (II), and layer III pyramidal cells (Pyr). > indicates significant difference; = indicates no significant difference.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial entorhinal cortex layer III pyramidal cell AHP amplitude (mV) 7.0 ± 0.4 7.0 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell resting membrane potential (mV) -55.0 ± 1.5 -55.0 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell input resistance (MΩ) 49.0 ± 3.0 49.0 (MΩ) Data Table
Medial entorhinal cortex layer III pyramidal cell cell capacitance (pF) 130.0 ± 9.0 130.0 (pF) Data Table
Medial entorhinal cortex layer III pyramidal cell spike half-width (ms) 0.5 ± 0.04 0.5 (ms) Data Table