Article: Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Arrigoni E; Chamberlin NL; Saper CB; McCarley RW Neuroscience, 2006
Table 1Electrophysiological properties of 192IgG-positive/ChAT-positive neurons and ChAT-positive neurons from uninjected animals are identical
Values are presented as means±SEM (n, number of cells). Significant differences were determined by unpaired t-test. Physiological parameters were calculated as described in the Experimental Procedures section.
Property | 192IgG/ChAT (+) neurons (n=45) | ChAT (+) neurons (n=14) | t-Test |
Resting potential (mV) | −55.3±1.2(n=45) | −55.2±1.6(n=14) | P=0.959 |
Input resistance (MΩ) | 343±22(n=45) | 381±26(n=14) | P=0.265 |
Presence of spontaneous firing; rate (Hz) | 15%(n=40);1.4±0.3(n=6) | 15%(n=13);1.6±0.1(n=2) | P=0.517 |
Spike half-width (ms) | 2.95±0.18(n=45) | 2.91±0.33(n=14) | P=0.907 |
AHP amplitude (mV) | −12.9±0.90(n=15) | −11.2±2.02(n=8) | P=0.443 |
AHP duration (ms) | 360±32(n=15) | 315±64(n=8) | P=0.546 |
Presence of accommodation | 100%(n=14) | 100%(n=6) | |
Depolarizing sag (mV) (Ih activation) | +1.12±0.34mV(n=30) | +0.46±0.46mV(n=10) | P=0.260 |
Percentage of neurons inhibited by AD | 83%(n=35) | 83%(n=6) |