Table 1Comparison of membrane properties of NAc neurons in wild-type and Fos mutant mice.
Group
Wild-type
Mutant
Number of neurons
10
12
Passive membrane properties
RMP (mV)
−79.02±0.93
−79.37±0.41
Rin (mW)
128.65±24.59
159.17±15.90
Active membrane properties
Current to generate AP (nA)
0.29±0.04
0.20±0.01*
AP threshold (mV)
−33.93±1.09
−34.27±1.19
AP amplitude (mV)
74.86±1.86
67.83±1.67*
1/2 AP duration (ms)
1.09±0.05
1.17±0.04
AHP amplitude (mV)
13.51±1.05
9.83±0.67*
The passive and active membrane properties of medium spiny NAc neurons were measured by current clamp recordings from brain slices of wild-type and f/fc-fos-D1-cre mice. Values represent the mean±SEM for the number of neurons indicated (*p<0.05; Student's t-test). RMP: resting membrane potential; AP: action potential; AHP: after-hyperpolarization.
