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Article: Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.

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Wang Y; Kuehl-Kovarik MC
Brain Res., 2012


Table 1Effect of estradiol (1nM) or ER agonists (10nM) on sodium currents and action potentials in isolated GnRH neurons from young female mice.
PropertyYoung controlYoung estradiolYoung DPNYoung PPT
AMPMAMPMAMPMAMPM
Sodium currents
Amplitude (pA/pF)532.58±28.0−475.18±24.0−405.57±36.5a−551.0±13.0b−357.10±34.6a−503.66±44.4b−443.11±55.5−556.60±45.9
n=25n=24n=15n=13n=12n=10n=10n=10
Riseslope (V/ms) (maximum)−21.43±1.8−19.50±1.9−14.30±1.6a−20.48±2.9−15.12±2.4a−21.40±3.1−22.30±3.9−30.61±6.9
n=21n=22n=11n=10n=12n=10n=7n=7
Decay slope (V/ms) (maximum)12.92±1.112.49±1.08.59±1.0a13.27±1.99.42±1.2a13.63±1.912.26±2.319.11±4.3
n=21n=22n=11n=10n=12n=10n=7n=7
Width (1/2 max; ms)0.47±0.0060.49±0.020.49±0.020.48±0.020.50±0.01a0.44±0.007b,c0.48±0.010.47±0.008
Action potentials
amplitude (mV)128.6±1.07126.8±2.39125.4±3.42129.1±1.17126.2±2.0126.5±1.67131.9±0.9125.4±1.5
n=17n=14n=8n=9n=9n=7n=4n=3
Width (1/2 max; ms)1.55±0.071.53±0.071.64±0.131.50±0.071.72±0.12d1.46±0.051.65±0.081.53±0.15
n=17n=14n=8n=9n=9n=7n=4n=3
AHP amplitude (mV)−4.65±0.55−4.48±0.54−4.35±0.44−3.82±0.46−3.82±1.05−3.20±0.82−4.46±0.09−4.30±0.27
n=17n=14n=8n=9n=9n=7n=4n=3
DAP amplitude (mV)4.68±0.264.66±0.233.51±0.41a4.07±0.534.79±0.683.51±0.51c6.27±0.62e4.19±0.28
n=23n=16n=11n=10n=9n=7n=4n=3
aSignificantly different from AM control (p<0.05).bSignificantly different from same-treatment AM (p<0.05).cSignificantly different from PM control (p<0.05).dSignificantly different from same-treatment PM (p<0.05).eSignificantly larger than AM control or estradiol DAP (p<0.05).

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike half-width 1.46 ± 0.05 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike half-width 1.65 ± 0.08 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike half-width 1.53 ± 0.15 -- Data Table
Other Hypothalamus GnRH-expressing neuron. AHP amplitude (mV) -4.65 ± 0.55 4.65 (mV) Data Table
Other Hypothalamus GnRH-expressing neuron. AHP amplitude (mV) -4.48 ± 0.54 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron AHP amplitude (mV) -4.35 ± 0.44 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron AHP amplitude (mV) -3.82 ± 0.46 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) AHP amplitude (mV) -3.82 ± 1.05 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) AHP amplitude (mV) -3.2 ± 0.82 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) AHP amplitude (mV) -4.46 ± 0.09 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) AHP amplitude (mV) -4.3 ± 0.27 -- Data Table
Other Hypothalamus GnRH-expressing neuron. ADP amplitude (mV) 4.68 ± 0.26 4.68 (mV) Data Table
Other Hypothalamus GnRH-expressing neuron. ADP amplitude (mV) 4.66 ± 0.23 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron ADP amplitude (mV) 3.51 ± 0.41 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron ADP amplitude (mV) 4.07 ± 0.53 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) ADP amplitude (mV) 4.79 ± 0.68 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) ADP amplitude (mV) 3.51 ± 0.51 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) ADP amplitude (mV) 6.27 ± 0.62 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) ADP amplitude (mV) 4.19 ± 0.28 -- Data Table
Other Hypothalamus GnRH-expressing neuron. spike amplitude from resting (mV) 128.6 ± 1.07 128.6 (mV) Data Table
Other Hypothalamus GnRH-expressing neuron. spike amplitude from resting (mV) 126.8 ± 2.39 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike amplitude from resting (mV) 125.4 ± 3.42 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike amplitude from resting (mV) 129.1 ± 1.17 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike amplitude from resting (mV) 126.2 ± 2.0 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike amplitude from resting (mV) 126.5 ± 1.67 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike amplitude from resting (mV) 131.9 ± 0.9 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with 4,4′, 4″-(4-propyl-[1H]-pyrazole-1,3,3-triyl)trisphenol (estrogen receptor-α agonist) spike amplitude from resting (mV) 125.4 ± 1.5 -- Data Table
Other Hypothalamus GnRH-expressing neuron. spike half-width 1.55 ± 0.07 1.55 (ms) Data Table
Other Hypothalamus GnRH-expressing neuron. spike half-width 1.53 ± 0.07 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike half-width 1.64 ± 0.13 -- Data Table
Other Hypothalamus GnRH-expressing estradiol-treated neuron spike half-width 1.5 ± 0.07 -- Data Table
Other Hypothalamus GnRH-expressing neuron treated with diarylpropionitrile (estrogen receptor-β agonist) spike half-width 1.72 ± 0.12 -- Data Table