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Article: Action potential initiation and propagation in layer 5 pyramidal neurons of the rat prefrontal cortex: absence of dopamine modulation.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Gulledge AT; Stuart GJ J. Neurosci., 2003
Table 1.
Summary of statistically significant effects of dopamine (10 μm) on pyramidal neuron physiology
| n (control/DA) | Control | 10 μm DA | Change in DA (p < 0.05 for all) | |
|---|---|---|---|---|
| VM (soma) | 37/25 | −80.4 ± 0.5 mV | −78.1 ± 0.7 mV | 2.5 ± 0.4 mV |
| VM (dendrite) | 40/36 | −77.9 ± 0.6 mV | −74.8 ± 0.6 mV | 3.0 ± 0.4 mV |
| RN (soma) | 8 | 88 ± 15 MΩ | 80 ± 6 MΩ | −7.7 ± 2.5% |
| RN (dendrite) | 11 | 55 ± 6 MΩ | 46 ± 6 MΩ | −16.9 ± 2.0% |
| Excitability (with depolarization) | 21 | 5.2 ± 0.4 spikes | 6.5 ± 0.8 spikes | 20 ± 9% |
| Excitability (hyperpolarized) | 12 | 5.8 ± 0.6 spikes | 2.7 ± 0.9 spikes | −58 ± 13% |
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Excitability was measured either during dopamine-induced depolarization (with depolarization) or with the membrane potential adjusted to control levels with a somatic DC bias current (hyperpolarized). Excitability was measured as number of spikes in response to a given somatic current injection (∼300 pA, 1 sec). Rn, Input resistance; Vm, resting membrane potential.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 5-6 | Layer 5 medial prefrontal prelimbic cortex pyramidal neurons | input resistance | 88.0 ± 15.0 (37) | 88.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Layer 5 medial prefrontal prelimbic cortex pyramidal neurons | resting membrane potential | -80.4 ± 0.5 (37) | -80.4 (mV) | Data Table |