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Article: Psychostimulant-induced plasticity of intrinsic neuronal excitability in ventral subiculum.

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Cooper DC; Moore SJ; Staff NP; Spruston N
J. Neurosci., 2003


Table 1.

In vitro electrophysiological properties of vSUB during withdrawal from amphetamine

SAL/EW AMPH/EW SAL/LW AMPH/LW
RS BS RS BS RS BS RS BS
Vm (mV) -73.4 ± 1.0 -73.1 ± 0.9 -70.5 ± 0.8 -69.3 ± 0.8 -69.9 ± 1.0 -68.9 ± 1.1 -72.1 ± 1.1 -67.8 ± 1.2
Rn (MΩ) 57.5 ± 5.7 65.1 ± 7.6 64.31 ± 5.8 65.0 ± 7.0 54.5 ± 5.0 54.1 ± 7.2 65.4 ± 4.6 56.5 ± 5.6
600 msec rheobase (pA) 135 ± 25 144 ± 19 174 ± 31 198 ± 31 194 ± 27 196 ± 40 135 ± 22 205 ± 24
600 msec threshold (mV) -48.5 ± 1.1 -50.0 ± 0.8** -46.9 ± 1.2 -46.6 ± 0.6** -47.9 ± 1.9 -47.5 ± 1.2 -48.6 ± 1.7 -46.4 ± 0.8
Amplitude (mV) 93.9 ± 2.0 95.5 ± 1.6* 92.6 ± 2.2 89.3 ± 2.8* 95.9 ± 1.6 95.1 ± 1.6 91.3 ± 2.4 95.7 ± 3.6
dV/dt (V/sec) 479 ± 22 521 ± 29* 451 ± 19 459 ± 25* 557 ± 26 556 ± 26 533 ± 45 511 ± 24
Half-width (msec) 0.72 ± 0.02 0.71 ± 0.02 0.72 ± 0.03 0.69 ± 0.03 0.69 ± 0.03 0.66 ± 0.03 0.66 ± 0.04 0.70 ± 0.03
SEPSC rheobase (pA) 980 ± 150 812 ± 79 1000 ± 109 881 ± 110 846 ± 107 702 ± 115 830 ± 125 974 ± 180
SEPSC burst rheobase (pA) 1113 ± 74** NA 1570 ± 127* NA 1280 ± 178 NA 1571 ± 142 NA
SEPSC threshold (mV) -52.1 ± 1.4 -52.7 ± 0.8* -50.4 ± 1.0 -49.6 ± 0.9* -51.9 ± 0.6 -50.4 ± 1.4 -48.6 ± 1.7 -49.3 ± 1.3

  • Electrophysiological properties of vSUB neurons at early and late withdrawal times from repeated amphetamine treatment. For both regular spiking (RS) and burst spiking (BS) neurons, measurements of the passive properties of input resistance (RN) and resting potential (Vm) are presented for the two groups (SAL and AMPH) at an early withdrawal (EW) or late withdrawal (LW) time point. Active properties of the action potentials, such as half-width, threshold, amplitude, and minimum current needed to trigger an action potential (rheobase) were assessed using either a 600 msec current step pulse or an sEPSC input. The minimum sEPSC injection required to initiate a burst in an RS cell (sEPSC rheobase) was performed only in RS cells. ANOVA and two-tailed t test were used to compare treatment groups within each withdrawal time between each neuron classification (RS and BS). All groups were composed of 8-19 different cells with no more than 2 cells from a single rat. *p < 0.05; **p < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Subiculum pyramidal cell Ventral subiculum regular spiking pyramidal neuron input resistance (MΩ) 57.5 ± 5.7 (8) 57.5 (MΩ) Data Table
Subiculum pyramidal cell Ventral subiculum regular spiking pyramidal neuron resting membrane potential (mV) -73.4 ± 1.0 (8) -73.4 (mV) Data Table
Subiculum pyramidal cell Ventral subiculum regular spiking pyramidal neuron rheobase (pA) 135.0 ± 25.0 (8) 135.0 (pA) Data Table
Subiculum pyramidal cell Ventral subiculum regular spiking pyramidal neuron spike threshold (mV) -48.5 ± 1.1 (8) -48.5 (mV) Data Table
Subiculum pyramidal cell Ventral subiculum regular spiking pyramidal neuron spike amplitude (mV) 93.9 ± 2.0 (8) 93.9 (mV) Data Table
Subiculum pyramidal cell Ventral subiculum regular spiking pyramidal neuron spike rise time (V/sec) 479.0 ± 22.0 (8) -- Data Table
Subiculum pyramidal cell Ventral subiculum regular spiking pyramidal neuron spike half-width (msec) 0.72 ± 0.02 (8) 0.72 (ms) Data Table