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Article: Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Bacci A; Rudolph U; Huguenard JR; Prince DA J. Neurosci., 2003
Membrane and firing properties of FS and LTS interneurons
| FS | LTS | |
|---|---|---|
| Membrane resistance (MΩ) | 68.7 ± 3.9 | 130.9 ± 12.2 |
| Action potential half-width (msec)a | 0.2 ± 0.01 | 0.52 ± 0.03 |
| AHP amplitude (mV)ab | 24.3 ± 0.7 | 16.5 ± 0.7 |
| Maximal firing frequency (Hz)c | 167.2 ± 8.5 | 75.7 ± 6.1 |
| f-i slope (Hz/pA)ad | 0.2 ± 0.02 | 0.05 ± 0.004 |
| Spike frequency adaptatione | 1.1 ± 0.06 | 0.8 ± 0.03 |
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All values are means ± SEM; n = 18 for FS interneurons; n = 16 for LTS interneurons. Independent t test comparisons produced p < 0.001 for all above parameters.
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↵ a Ranges completely nonoverlapping.
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↵ b AHP, Afterhyperpolarization; calculated as the difference between the action potential threshold and the most negative level reached during the repolarizing phase.
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↵ c Calculated from total spikes elicited by 600-msec-long current injections of 800 pA.
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↵ d f-i slope = firing frequency versus injected current slope, with current injections ranging from 400 to 800 pA.
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↵ e Spike frequency adaptation was calculated as the ratio of the instantaneous frequency at the fourth and last spike intervals in an action potential train.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron | maximum firing rate (Hz) | 167.2 ± 8.5 (18) | 167.2 (Hz) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron | maximum firing rate (Hz) | 75.7 ± 6.1 (16) | 75.7 (Hz) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron | FI slope (Hz/pA) | 0.2 ± 0.02 (18) | 200.0 (Hz/nA) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron | FI slope (Hz/pA) | 0.05 ± 0.004 (16) | 50.0 (Hz/nA) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron | adaptation ratio (last/first ISI) | 1.1 ± 0.06 (18) | 1.1 (ratio) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron | adaptation ratio (last/first ISI) | 0.8 ± 0.03 (16) | 0.8 (ratio) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron | input resistance (MΩ) | 68.7 ± 3.9 (18) | 68.7 (MΩ) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron | input resistance (MΩ) | 130.9 ± 12.2 (16) | 130.9 (MΩ) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron | spike half-width (msec) | 0.2 ± 0.01 (18) | 0.2 (ms) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron | spike half-width (msec) | 0.52 ± 0.03 (16) | 0.52 (ms) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron | AHP amplitude (mV) | 24.3 ± 0.7 (18) | 24.3 (mV) | Data Table |
| Neocortex basket cell | Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron | AHP amplitude (mV) | 16.5 ± 0.7 (16) | 16.5 (mV) | Data Table |