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Article: Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Bacci A; Rudolph U; Huguenard JR; Prince DA
J. Neurosci., 2003


Table 1.

Membrane and firing properties of FS and LTS interneurons

FS LTS
Membrane resistance (MΩ) 68.7 ± 3.9 130.9 ± 12.2
Action potential half-width (msec)a 0.2 ± 0.01 0.52 ± 0.03
AHP amplitude (mV)ab 24.3 ± 0.7 16.5 ± 0.7
Maximal firing frequency (Hz)c 167.2 ± 8.5 75.7 ± 6.1
f-i slope (Hz/pA)ad 0.2 ± 0.02 0.05 ± 0.004
Spike frequency adaptatione 1.1 ± 0.06 0.8 ± 0.03
  • All values are means ± SEM; n = 18 for FS interneurons; n = 16 for LTS interneurons. Independent t test comparisons produced p < 0.001 for all above parameters.

  • a Ranges completely nonoverlapping.

  • b AHP, Afterhyperpolarization; calculated as the difference between the action potential threshold and the most negative level reached during the repolarizing phase.

  • c Calculated from total spikes elicited by 600-msec-long current injections of 800 pA.

  • d f-i slope = firing frequency versus injected current slope, with current injections ranging from 400 to 800 pA.

  • e Spike frequency adaptation was calculated as the ratio of the instantaneous frequency at the fourth and last spike intervals in an action potential train.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron maximum firing rate (Hz) 167.2 ± 8.5 (18) 167.2 (Hz) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron maximum firing rate (Hz) 75.7 ± 6.1 (16) 75.7 (Hz) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron FI slope (Hz/pA) 0.2 ± 0.02 (18) 200.0 (Hz/nA) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron FI slope (Hz/pA) 0.05 ± 0.004 (16) 50.0 (Hz/nA) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron adaptation ratio (last/first ISI) 1.1 ± 0.06 (18) 1.1 (ratio) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron adaptation ratio (last/first ISI) 0.8 ± 0.03 (16) 0.8 (ratio) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron input resistance (MΩ) 68.7 ± 3.9 (18) 68.7 (MΩ) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron input resistance (MΩ) 130.9 ± 12.2 (16) 130.9 (MΩ) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron spike half-width (msec) 0.2 ± 0.01 (18) 0.2 (ms) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron spike half-width (msec) 0.52 ± 0.03 (16) 0.52 (ms) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting fast-spiking GABAergic basket interneuron AHP amplitude (mV) 24.3 ± 0.7 (18) 24.3 (mV) Data Table
Neocortex basket cell Sensorimotor cortex layer V locally projecting low threshold-spiking GABAergic basket interneuron AHP amplitude (mV) 16.5 ± 0.7 (16) 16.5 (mV) Data Table