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Article: Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex.

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Stephens EK; Avesar D; Gulledge AT
Front Neural Circuits, 2014


Comparison of 5-HT responses in CPn neurons with and without 2A receptors.

CPn neuron subtype n RMP (mV) RN (MΩ) Sag (%) Duration of inhibition (s)
During low frequency firing During high frequency firing
No revealed 2A-excitation 21 -76 ± 1 82 ± 6 12 ± 1 31 ± 3 20 ± 2
Revealed 2A-excitation 10 -76 ± 1 83 ± 11 14 ± 1 21 ± 3* 17 ± 4
Asterisk indicates p< 0.05 vs CPn neurons without revealed 2A responses.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5 corticopontine pyramidal excitatory neurons without 2A receptors sag ratio 12.0 ± 1.0 (21) 0.12 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5 corticopontine pyramidal excitatory neurons with 2A receptors resting membrane potential (mV) -76.0 ± 1.0 (10) -76.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5 corticopontine pyramidal excitatory neurons with 2A receptors input resistance (MΩ) 83.0 ± 11.0 (10) 83.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5 corticopontine pyramidal excitatory neurons with 2A receptors sag ratio 14.0 ± 1.0 (10) 0.14 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5 corticopontine pyramidal excitatory neurons without 2A receptors resting membrane potential (mV) -76.0 ± 1.0 (21) -76.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Prefrontal cortex layer 5 corticopontine pyramidal excitatory neurons without 2A receptors input resistance (MΩ) 82.0 ± 6.0 (21) 82.0 (MΩ) Data Table