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Article: Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus.

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Cloues RK; Sather WA
J. Neurosci., 2003


Table 1.

Membrane properties of slow- and fast-firing cluster I neurons

Depolarizing ramp (mV/msec) Interspike potential (mV) Spike width (msec) Spike amplitude (mV) Maximum hyperpolarization (mV) AHP t½(msec) Cd2+-subtracted AHP IBTX-subtracted AHP
t½ (msec) Amplitude (mV) t½ (msec) Amplitude (mV)
Number of cells (n) 9 9 9 9 9 9 6 6 5 5
Slow rate (<3 Hz) 0.23  ± 0.01 −41.3  ± 1.9 4.0  ± 0.1 82.8  ± 1.7 −53.8  ± 1.6 37.3  ± 5.0 7.1  ± 0.9 11.0  ± 3.8 2.8  ± 0.8 17.4  ± 3.3
Fast rate (>6 Hz) 0.25  ± 0.03 −44.7  ± 2.3 3.0  ± 0.1 77.7  ± 3.6 −58.1  ± 2.2 17.8  ± 0.9 3.1  ± 0.4 26.0  ± 2.9 3.1  ± 0.7 10.4  ± 2.0
p NS NS 0.0001 NS NS 0.001 0.003 0.01 NS NS
  • Membrane properties were compared between slow (<3 Hz) and fast (>6 Hz) spontaneously firing cluster I SCN neurons. The depolarizing ramp was measured as the rate of voltage change (mV/msec) over the 50 msec preceding action potential threshold. Interspike potential (V IP) was estimated as the plateau region between action potentials. For fast-spiking neurons in which interspike plateaus were mostly brief, V IP was estimated using the longer interspike intervals recorded from these irregularly firing neurons. Spike width was measured at action potential threshold. Spike amplitude was measured from V IP to maximum depolarization. Maximum hyperpolarization reached during the AHP was measured from 0 mV. t ½ for the AHP and Cd2+-subtracted AHP was estimated as the half-decay time. For measurements of Cd2+-subtracted AHPs, slow-firing cells included those firing at <5 Hz. Statistical significance (pvalues) for differences between fast- and slow-firing neurons is indicated at the bottom of each column, with p ≥ 0.05 considered not significant (NS).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 slow-firing neuron resting membrane potential (mV) -41.3 ± 1.9 (9) -41.3 (mV) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 slow-firing neuron spike width (msec) 4.0 ± 0.1 (9) 4.0 (ms) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 slow-firing neuron spike amplitude from resting (mV) 82.8 ± 1.7 (9) 82.8 (mV) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 slow-firing neuron AHP voltage (mV) -53.8 ± 1.6 (9) -53.8 (mV) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 slow-firing neuron fast AHP duration (msec) 37.3 ± 5.0 (9) 37.3 (ms) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 fast-firing neuron resting membrane potential (mV) -44.7 ± 2.3 (9) -44.7 (mV) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 fast-firing neuron spike width (msec) 3.0 ± 0.1 (9) 3.0 (ms) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 fast-firing neuron spike amplitude from resting (mV) 77.7 ± 3.6 (9) 77.7 (mV) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 fast-firing neuron AHP voltage (mV) -58.1 ± 2.2 (9) -58.1 (mV) Data Table
Suprachiasmatic nucleus neuron Suprachiasmatic nucleus cluster 1 fast-firing neuron fast AHP duration (msec) 17.8 ± 0.9 (9) 17.8 (ms) Data Table