TABLE 1.Morphological parameters of CT, CC1, and CC2 pyramidal neurons
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| Morphological Parameters | CT (21) | CC (22) | P Value | ROC Area | CC1 (6) | CC2 (11) | P Value | ROC Area |
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| Dist. from pial surface, µm | 1430 ± 129 | 1452 ± 176 | 0.58 | 1600 ± 177 | 1397 ± 144 | 1.2E-02 | 0.81 | |
| Dist. from L4-L5 border, µm | –632 ± 119 | –652 ± 108 | 0.57 | –729 ± 107 | –622 ± 96 | 3.7E-02 | 0.79 | |
| Depth from slice surface, µm | –27.4 ± 12.3 | –25.1 ± 10.3 | 0.53 | –19.0 ± 4.9 | –27.5 ± 10.9 | 0.11 | ||
| Soma horizontal diameter, µm | 11.8 ± 2.1 | 12.6 ± 2.0 | 0.15 | 12.3 ± 2.2 | 12.8 ± 2.1 | 0.79 | ||
| Soma area, µm2 | 136.7 ± 43.2 | 151.1 ± 42.7 | 0.53 | 153.3 ± 36.2 | 150.2 ± 46.2 | 0.89 | ||
| Soma + dend. area, µm2 | 7934 ± 1802 | 10137 ± 3185 | 8.7E-03 | 0.75 | 11962 ± 3463 | 9408 ± 2865 | 0.10 | |
| Basal dendrite length, µm | 1266 ± 412 | 1478 ± 432 | 2.9E-02 | 0.67 | 1649 ± 240 | 1409 ± 477 | 0.40 | |
| Apical dendrite length, µm | 2602 ± 510 | 2438 ± 477 | 0.53 | 2031 ± 456 | 2601 ± 390 | 9.3E-03 | 0.87 | |
| No. of total ends | 25.7 ± 5.2 | 20.8 ± 4.6 | 1.1E-03 | 0.85 | 21.3 ± 4.9 | 20.6 ± 4.6 | 0.53 | |
| No. of cut ends | 9.9 ± 3.2 | 9.0 ± 4.1 | 0.45 | 6.7 ± 2.7 | 10.0 ± 4.2 | 0.09 | ||
| No. of basal dendrite branches | 22.5 ± 7.4 | 24.2 ± 5.0 | 0.37 | 24.3 ± 2.2 | 24.1 ± 5.9 | 0.99 | ||
| No. of apical dendrite branches | 44.1 ± 8.5 | 30.1 ± 7.2 | 1.3E-06 | 0.92 | 26.0 ± 5.6 | 32.9 ± 5.7 | 2.1E-02 | 0.80 |
| Avg. basal branch order | 2.1 ± 0.3 | 2.4 ± 0.3 | 9.3E-03 | 0.72 | 2.3 ± 0.2 | 2.4 ± 0.3 | 0.39 | |
| Avg. apical branch order | 9.8 ± 1.6 | 7.1 ± 1.3 | 2.2E-07 | 0.93 | 6.2 ± 0.8 | 7.6 ± 1.0 | 4.7E-03 | 0.85 |
| Percentage of dendrite in L4 | 8.7 ± 5.7 | 4.2 ± 3.9 | 4.3E-03 | 0.75 | 0.8 ± 1.3 | 5.5 ± 3.8 | 1.4E-02 | 0.88 |
| Percentage of dendrite in L5a | 13.4 ± 5.0 | 10.7 ± 5.4 | 0.10 | 4.9 ± 3.7 | 13.0 ± 4.1 | 4.9E-04 | 0.92 | |
| Percentage of dendrite in L5b | 27.0 ± 14.4 | 27.6 ± 16.0 | 0.97 | 21.6 ± 6.2 | 30.1 ± 18.2 | 0.29 | ||
| Percentage of dendrite in L6 | 50.6 ± 16.6 | 57.1 ± 20.3 | 0.26 | 72.7 ± 9.8 | 50.8 ± 20.2 | 2.2E-02 | 0.87 | |
| Percentage of dendrite in L4 + L5a | 22.1 ± 5.1 | 14.7 ± 7.0 | 1.5E-03 | 0.77 | 6.8 ± 4.4 | 18.5 ± 4.9 | 2.1E-04 | 0.96 |
| Max. dendritic span, µm | 232 ± 39 | 341 ± 58 | 9.8E-09 | 0.95 | 318 ± 45 | 350 ± 61 | 0.26 | |
| Dend. span in L4, µm | 114 ± 53 | 169 ± 115 | 0.07 | 191 ± 161 | 165 ± 115 | 0.79 | ||
| Dend. span in L5a, µm | 131 ± 65 | 191 ± 107 | 0.03 | 119 ± 78 | 215 ± 106 | 0.08 | ||
| Dend. span in L5b, µm | 174 ± 42 | 256 ± 78 | 1.3E-04 | 0.82 | 238 ± 35 | 263 ± 88 | 0.51 | |
| Dend. span in L6, µm | 218 ± 44 | 300 ± 84 | 3.2E-04 | 0.85 | 314 ± 48 | 294 ± 96 | 0.64 | |
| Total axon length, µm | 3970 ± 1811 | 5041 ± 3315 | 0.27 | |||||
| Descending axon length, µm | 781 ± 269 | 595 ± 247 | 0.03 | 0.76 | ||||
| No. of axonal branches | 24.0 ± 11.3 | 33.6 ± 19.0 | 0.29 | |||||
| No. of primary branches | 3.9 ± 1.3 | 7.8 ± 2.4 | 1.1E-06 | 0.94 | ||||
| Soma to first branch, µm | 71.9 ± 14.1 | 80.6 ± 19.0 | 0.08 | |||||
| Soma to last branch, µm | 151.5 ± 61.5 | 291.7 ± 133.1 | 6.6E-04 | 0.86 | ||||
| Max. axonal span, µm | 222 ± 89 | 661 ± 205 | 1.0E-07 | 0.98 | ||||
Somatic, dendritic, and axonal parameters of the three pyramidal cell types in L6. Tree lengths with respect to laminar boundaries
are calculated after the normalization explained in the methods; absolute lengths reported are of the unaltered reconstructions.
Parameters differing significantly after the Bonferroni correction (P < 0.0042) are indicated in bold. Number of neurons are in parentheses. CT, Corticothalamic; CC1 & CC2, corticocortical 1
and 2, respectively; ROC, receiver-operate curve.