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Article: Antisense suppression of potassium channel expression demonstrates its role in maturation of the action potential.

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Vincent A; Lautermilch NJ; Spitzer NC
J. Neurosci., 2000


Table 1.

Properties of control and antisense-treated neurons

Parameters Controls AS to xKv3.1 Significance of comparison
NF FAS FAS*
Membrane potential (mV) −45.3  ± 0.6 (12) −44.4  ± 1.0 (9) −45.4  ± 0.6 (6) NS
Capacitance (pF/μm2) 22.9  ± 1.2 (12) 22.5  ± 1.7 (9) 21.4  ± 2.0 (6) NS
Input resistance (GΩ) 1.2  ± 0.1 (12) 1.4  ± 0.2 (9) 1.1  ± 0.1 (6) NS
I Kv density (pA/μm2, +40 mV) 1.2  ± 0.2 (12) 1.1  ± 0.2 (9) 0.5  ± 0.1 (6) FAS* vs FAS p < 0.05
FAS* vs controlp < 0.01
I Kv t 1/2 max (msec, +40 mV) 1.0  ± 0.1 (12) 1.0  ± 0.1 (9) 1.6  ± 0.1 (6) FAS* vs FAS p < 0.05
FAS* vs control p < 0.01
I Ca (peak) (pA/μm2) 0.3  ± 0.1 (6)  0.3 ± 0.1 (7) NS
AP duration (at 0 mV) (msec) 1.9  ± 0.1 (9) 1.9  ± 0.2 (9) 3.5  ± 0.6 (6) FAS* vs FAS p < 0.01
FAS* vs control p < 0.01
  • Properties of the resting membrane, whole-cell currents, and action potentials recorded from nonfluorescent neurons (NF, control) and from fluorescent neurons (F, receiving AS) at 1 d in culture. Fluorescent cells were assigned to the AS* category when mean values were different by >2 sd from values for NF controls in the same culture dish. The rest were placed in the AS category. Values are mean ± SEM for (n) neurons from ≥3 experiments. NS, Not significantly different.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Xenopus spinal neurons input resistance (GΩ) 1.2 ± 0.1 (12) 1200.0 (MΩ) Data Table
Other Xenopus spinal neurons resting membrane potential (mV) -45.3 ± 0.6 (12) -45.3 (mV) Data Table
Other Xenopus spinal neurons spike width 1.9 ± 0.1 (9) 1.9 (ms) Data Table
Other Xenopus spinal neurons cell capacitance 22.9 ± 1.2 (12) 22.9 (pF) Data Table