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Article: A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex.

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Aramakis VB; Hsieh CY; Leslie FM; Metherate R
J. Neurosci., 2000


Table 1.

EPSPs in layers II–IV pyramidal neurons of rat auditory cortex during normal development and after CNE 1-a

Age/condition Stimulus intensity (μA) Latency to peak (msec) Peak (mV) EPSP width @ one-third peak EPSP width @ one-half peak EPSP width @ two-thirds peak n
Development
 P8–12 26.5  ± 7.0 16.8  ± 4.7 12.1  ± 1.3 107.8  ± 12.3 73.0  ± 8.5 50.6  ± 6.6 12
 P13–16 22.7  ± 3.6 9.2  ± 0.7 15.3  ± 1.2 66.5  ± 7.7 48.3  ± 6.9 28.4  ± 1.9 17
 P20–22 15.5  ± 5.0 5.7  ± 0.4 17.7  ± 1.0 34.5  ± 1.8 24.5  ± 1.4 16.4  ± 1.1 13
 P24–26 12.4  ± 3.5 4.9  ± 0.5 23.0  ± 2.5 27.1  ± 2.4 18.3  ± 2.2 12.8  ± 1.6 5
Control 38.8  ± 12.4 20.9  ± 8.7 11.0  ± 1.7 102.9  ± 16.7 72.7  ± 14.6 52.4  ± 12.1 6
CNE group I 50.0  ± 15.8 20.0  ± 5.5 7.9  ± 2.2 115.5  ± 14.7 80.6  ± 10.2 53.6  ± 6.7 5
Control 20.7  ± 2.9 10.2  ± 1.2 14.9  ± 1.1 76.3  ± 8.6 53.4  ± 6.2 32.8  ± 2.9 22
CNE group II
 1 mg/kg 19.0  ± 2.6 14.5  ± 2.9 13.5  ± 1.3 112.3  ± 11.81-b 82.9  ± 10.41-b 61.9  ± 8.91-b 13
 2 mg/kg 17.5  ± 1.4 17.5  ± 4.1 12.9  ± 1.2 118.5  ± 14.91-b 82.4  ± 11.71-b 60.8  ± 10.01-b 9
Control 10.1  ± 2.5 4.7  ± 0.3 21.2  ± 2.0 27.3  ± 1.9 18.5  ± 1.5 12.7  ± 1.1 8
CNE group III 9.5  ± 1.8 14.8  ± 4.6 16.3  ± 2.0 46.6  ± 5.91-b 36.6  ± 5.51-b 28.8  ± 5.11-b 7
Control 10.1  ± 2.5 4.7  ± 0.3 21.2  ± 2.0 27.3  ± 1.9 18.5  ± 1.5 12.7  ± 1.1 8
CNE group IV 12.1  ± 2.6 5.6  ± 1.2 20.3  ± 1.6 33.7  ± 2.2 24.3  ± 2.4 17.1  ± 2.5 9
  • F1-a Measurements from maximal subthreshold EPSPs.

  • F1-b Significantly different from control; ANOVA, p < 0.05.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source