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Article: A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Aramakis VB; Hsieh CY; Leslie FM; Metherate R
J. Neurosci., 2000


Table 2.

Intrinsic membrane properties of layers II–IV pyramidal neurons in rat auditory cortex during normal development and after CNE

Age/condition RMP (mV) Ri (MΩ) τ (msec) Spike threshold (mV) Spike height (mV) Spike width (msec) n
Development
 P8-12 −64.3  ± 0.7 282.2  ± 10.6 22.9  ± 0.7 −38.7  ± 0.5 65.6  ± 1.0 1.2  ± .03 53
 P13-16 −68.4  ± 0.6 195.6  ± 7.7 18.1  ± 0.4 −41.1  ± 0.4 72.8  ± 0.8 1.1  ± 0.3 70
 P20-22 −72.9  ± 1.6 72.5  ± 7.2 11.9  ± 0.6 −40.9  ± 0.6 74.3  ± 1.1 0.74  ± .03 15
 P24-26 −76.8  ± 1.5 49.8  ± 6.1 8.2  ± 0.5 −38.9  ± 1.8 76.4  ± 2.6 0.68  ± .03 7
Control −64.8  ± 1.1 305.2  ± 19.6 21.6  ± 1.0 −38.2  ± 0.8 63.8  ± 1.5 1.1  ± .04 16
CNE Group I −60.8  ± 1.2 300.0  ± 24.2 23.3  ± 2.3 −33.1  ± 2.42-a 50.8  ± 3.42-a 1.5  ± .122-a 5
Control −67.5  ± 0.6 220.5  ± 7.5 19.6  ± 0.5 −40.6  ± 0.4 71.3  ± 0.9 1.1  ± .02 71
CNE Group II −64.3  ± 1.3 200.4  ± 11.0 20.2  ± 0.9 −40.0  ± 0.5 67.3  ± 1.2 0.95  ± 0.022-a 22
Control −75.1  ± 1.9 59.0  ± 10.4 8.3  ± 0.3 −39.7  ± 1.3 75.4  ± 2.2 0.66  ± 0.03 10
CNE Group III −75.7  ± 2.1 60.9  ± 9.0 8.6  ± 0.8 −42.0  ± 1.7 75.8  ± 2.1 0.75  ± 0.06 7
Control −75.1  ± 1.9 59.0  ± 10.4 8.3  ± 0.3 −39.7  ± 1.3 75.4  ± 2.2 0.66  ± 0.03 10
CNE Group IV −76.7  ± 1.2 53.3  ± 4.3 8.3  ± 0.3 −43.0  ± 1.4 79.3  ± 2.4 0.72  ± 0.03 9

  • ↵F2-a Significantly different from control; ANOVA, p < 0.05.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron resting membrane potential (mV) -64.3 ± 0.7 (53) -64.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron input resistance (MΩ) 282.2 ± 10.6 (53) 282.2 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron membrane time constant (msec) 22.9 ± 0.7 (53) 22.9 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike threshold (mV) -38.7 ± 0.5 (53) -38.7 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike amplitude (mV) 65.6 ± 1.0 (53) 65.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike half-width (msec) 1.2 ± 0.03 (53) 1.2 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron resting membrane potential (mV) -68.4 ± 0.6 (70) -68.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron input resistance (MΩ) 195.6 ± 7.7 (70) 195.6 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron membrane time constant (msec) 18.1 ± 0.4 (70) 18.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike threshold (mV) -41.1 ± 0.4 (70) -41.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike amplitude (mV) 72.8 ± 0.8 (70) 72.8 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike half-width (msec) 1.1 ± 0.3 (70) 1.1 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron resting membrane potential (mV) -72.9 ± 1.6 (15) -72.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron input resistance (MΩ) 72.5 ± 7.2 (15) 72.5 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron membrane time constant (msec) 11.9 ± 0.6 (15) 11.9 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike threshold (mV) -40.9 ± 0.6 (15) -40.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike amplitude (mV) 74.3 ± 1.1 (15) 74.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike half-width (msec) 0.74 ± 0.03 (15) 0.74 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron resting membrane potential (mV) -76.8 ± 1.5 (7) -76.8 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron input resistance (MΩ) 49.8 ± 6.1 (7) 49.8 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron membrane time constant (msec) 8.2 ± 0.5 (7) 8.2 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike threshold (mV) -38.9 ± 1.8 (7) -38.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike amplitude (mV) 76.4 ± 2.6 (7) 76.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Auditory Cortex Layers 2-4 Pyramidal Neuron spike half-width (msec) 0.68 ± 0.03 (7) 0.68 (ms) Data Table