Article: Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
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Article Data (extracted)
Planert H; Berger TK; Silberberg G
PLoS ONE, 2013
10.1371/journal.pone.0057054.t005
Effect of dopamine (120 µM) on membrane properties of D1 and D2 MSNs.
|
D1 MSNs |
D2 MSNs |
|
Control |
DA |
|
|
Control |
DA |
|
|
|
mean |
SD |
mean |
SD |
n |
p |
mean |
SD |
mean |
SD |
n |
p |
Baseline current (pA) |
-4.17 |
60.03 |
-77.92 |
83.20 |
4 |
0.093 |
-8.88
|
87.23 |
-88.97
|
87.67 |
10 |
0.006
|
Baseline membrane potential (mV) |
-77.89 |
1.67 |
-77.02 |
2.05 |
5 |
0.284 |
-80.33 |
3.13 |
-78.87 |
4.81 |
9 |
0.247 |
Amplitude first AP (mV) |
80.73 |
5.33 |
77.80 |
3.13 |
5 |
0.126 |
74.16 |
9.05 |
71.94 |
7.27 |
10 |
0.203 |
Width first AP (ms) |
0.82 |
0.06 |
0.87 |
0.06 |
5 |
0.077 |
0.81
|
0.13 |
0.87
|
0.12 |
10 |
0.037
|
Amplitude second AP (mV) |
64.81 |
10.00 |
58.01 |
10.24 |
4 |
0.064 |
61.78
|
6.46 |
52.97
|
4.60 |
10 |
0.004
|
Width second AP (ms) |
1.10 |
0.19 |
1.13 |
0.17 |
4 |
0.546 |
1.05 |
0.19 |
1.08 |
0.15 |
10 |
0.376 |
Input resistance rest(MΩ ) |
79.96 |
37.56 |
88.78 |
39.73 |
5 |
0.103 |
112.80 |
58.51 |
102.40 |
46.01 |
10 |
0.219 |
Time constant for delta pulse (ms) |
5.02 |
1.47 |
4.51 |
1.43 |
5 |
0.105 |
6.47
|
3.22 |
5.06
|
2.99 |
10 |
0.013
|
Threshold for APs (mV) |
-44.15
|
2.88 |
-39.09
|
3.25 |
5 |
0.034
|
-42.36 |
4.29 |
-34.88 |
4.91 |
10 |
0.000
|
Ramp current to first spike (pA) |
325.46 |
142.54 |
339.13 |
176.90 |
5 |
0.507 |
245.90
|
95.11 |
302.60
|
121.90 |
10 |
0.007
|
Minimum step current for discharge (pA) |
329.98 |
161.40 |
366.55 |
221.63 |
5 |
0.255 |
251.20
|
105.00 |
309.10
|
128.40 |
9 |
0.004
|
Inferred neuron-electrophysiology data values
Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |