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Article: Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties.

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Hattox AM; Nelson SB
J. Neurophysiol., 2007



TABLE 1.Intrinsic membrane and firing properties of identified cortical projection neurons
CThal (1) CTrig (2) CStr (3) Callosal (4)
n 18 19 28 16
Vm mV –62.3 ± 0.4 –63.6 ± 0.6 –67.1 ± 0.6 –67.1 ± 0.7
***3 *3
***4
Rin MOhm 149.8 ± 5.2 143.3 ± 6.7 183.1 ± 13.3 157.9 ± 10.2
AP threshold, mV –42.3 ± 0.5 *2 –39.4 ± 0.6 –35.5 ± 0.5 –36.5 ± 0.7
***3 ***3
***4 *4
Half width, ms 0.91 ± 0.03 1.02 ± 0.05 1.17 ± 0.02 1.11 ± 0.02
***3 **3
***4
Adaptation ratio 0.96 ± 0.03 0.96 ± 0.05 0.33 ± 0.03 0.43 ± 0.05
***3 ***3
***4 ***4
FI slope, nAmp/msee 276.8 ± 17.9 293 ± 24.2 152.4 ± 18.0 154.9 ± 14.1
**3 ***3
***4 ***4
fAHP amplitude, mV 7.0 ± 1.0 **2 3.6 ± 0.8 1.5 ± 0.5 0.1 ± 0.1
***3
***4 *4
DAP amplitude, mV 7.2 ± 0.8 ***2 2.3 ± 0.4 1.2 ± 0.4 0.0 ± 0.0
***3
***4 *4
Values are reported as the means±SE for each class of neurons projecting to the same target. Each class of projection neuron was assigned a number (1–4) and statistics were calculated from one-way ANOVAs followed by the Scheffe post hoc test to compare means of pairs of projection neuron classes. Significant differences between pairs are indicated by the P value followed by the projection neuron class (1–4) to which it was compared.

* P < 0.05,

** 0.01,

*** 0.001. CThal, CTrig, and CStr, corticothalamic, corticotrigeminal, and corticostriatal; AP, action potential; FI, firing current; fAHP, fast afterhyperpolarization; DAP, depolarizing afterhyperpolarization.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons ADP amplitude (mV) 7.2 ± 0.8 (18) 7.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons ADP amplitude (mV) 2.3 ± 0.4 (19) 2.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons ADP amplitude (mV) 1.2 ± 0.4 (28) 1.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons ADP amplitude (mV) 0.0 -- Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons resting membrane potential (mV) -62.3 ± 0.4 (18) -62.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons resting membrane potential (mV) -63.6 ± 0.6 (19) -63.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons resting membrane potential (mV) -67.1 ± 0.6 (28) -67.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons resting membrane potential (mV) -67.1 ± 0.7 (16) -67.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons input resistance 149.8 ± 5.2 (18) 149.8 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons input resistance 143.3 ± 6.7 (19) 143.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons input resistance 183.1 ± 13.3 (28) 183.1 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons input resistance 157.9 ± 10.2 (16) 157.9 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons spike threshold (mV) -42.3 ± 0.5 (18) -42.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons spike threshold (mV) -39.4 ± 0.6 (19) -39.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons spike threshold (mV) -35.5 ± 0.5 (28) -35.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons spike threshold (mV) -36.5 ± 0.7 (16) -36.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons spike half-width (ms) 0.91 ± 0.03 (18) 0.91 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons spike half-width (ms) 1.02 ± 0.05 (19) 1.02 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons spike half-width (ms) 1.17 ± 0.02 (28) 1.17 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons spike half-width (ms) 1.11 ± 0.02 (16) 1.11 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons adaptation ratio 0.96 ± 0.03 (18) 0.96 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons adaptation ratio 0.96 ± 0.05 (19) 0.96 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons adaptation ratio 0.33 ± 0.03 (28) 0.33 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons adaptation ratio 0.43 ± 0.05 (16) 0.43 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons FI slope 276.8 ± 17.9 (18) 276.8 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons FI slope 293.0 ± 24.2 (19) 293.0 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons FI slope 152.4 ± 18.0 (28) 152.4 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons FI slope 154.9 ± 14.1 (16) 154.9 (Hz/nA) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticothalamic projecting thick tufted pyramidal neurons fast AHP amplitude (mV) 7.0 ± 1.0 (18) 7.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticotrigeminal projecting pyramidal thick tufted neurons fast AHP amplitude (mV) 3.6 ± 0.8 (19) 3.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticostriatal projecting slender tufted pyramidal neurons fast AHP amplitude (mV) 1.5 ± 0.5 (28) 1.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 corticocallosal projecting slender tufted pyramidal neurons fast AHP amplitude (mV) 0.1 ± 0.1 (16) 0.1 (mV) Data Table