Resting membrane potential | Number of evoked spikes | Action potential threshold (mV) | Rheobase current (pA) | Input resistance (MΩ) | Duration of first ISI (ms) | |
FS cells | ||||||
Control | -70.5 (±2.0) (n = 5) | 14.2 (±1.9) | -39.4 (±1.6) | 144.5 (±31.6) | 231.6 (±49.5) | 33.9 (±11.8) |
10 μM SKF 38393 or SKF 81297 (D1 agonists) (n = 12) | -69.5 (±1.8) (n = 5) | 20.6 (±3.2)* | -43.7 (±1.6)** | 121.3 (±24.6)* | 243.7 (±54.5) | 28.5 (±11.3)** |
Control | -70.0 (±0.0) (n = 3) | 14.4 (±2.1) | -40.8 (±2.1) | 113.9 (±34.1) | 224.4 (±60.4) | - |
10 μM quinpirole (D2 agonist) (n = 6) | -66.5 (±1.5) (n = 3) | 15.0 (±2.8) | -41.1 (±2.2) | 106.1 (±33.4) | 239.2 (±72.7) | - |
Control | - | 14.3 (±3.9) | -42.1 (±1.2) | 91.41 (±11.4) | 205.5 (±24.5) | - |
1 or 5 μM PD 168077 (D4 agonist) (n = 5) | - | 14.5 (±4.2) | -42.4 (±1.5) | 93.5 (±10.5) | 201.8 (±22.3) | - |
Control | - | 18.5 (±1.3) | -43.6 (±1.2) | 138.4 (±29.5) | 214.5 (±59.0) | - |
5 μM SCH23390 (D1 antagonist) (n = 7) | - | 19.3 (±2.5) | -43.7 (±1.3) | 134.2 (±28.1) | 218.7 (±59.3) | - |
5 μM SCH23390 + 50 μM DA (n = 7) | - | 19.6 (±2.6) | -44.3 (±1.2) | 132.1 (±28.0) | 222.2 (±59.8) | - |
Control | - | 13.1 (±3.8) | -43.3 (±2.0) | 105.4 (±24.1) | 193.3 (±40.9) | - |
5 μM sulpiride (D2 antagonist) (n = 5) | - | 16.1 (±5.0) | -44.2 (±1.8)** | 105.1 (±26.7) | 188.3 (±34.1) | - |
5 μM sulpiride + 10 μM DA (n = 5) | - | 26.3 (±5.6)** | -45.9 (±1.5) | 90.9 (±21.6) | 189.2 (±29.0) | - |
Adapting cells | ||||||
Control | -78.0 (±2.0) (n = 3) | 6.5 (±1.7) | -40.4 (±1.7) | 77.9 (±20.2) | 273.1 (±20.2) | 66.9 (±30.4) |
10 μM SKF 38393 or SKF 81297 (D1 agonists) (n = 8) | -74.5 (±2.0) | 7.3 (±1.1) | -43.3 (±2.1)* | 84.3 (±25.3) | 270.0 (±44.6) | 41.7 (±15.2) |
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Note: In the case of experiments involving antagonists, the effects of DA were compared with the effects of the antagonist alone. Significant differences compared with control or antagonist baseline condition, respectively, are indicated as * for P < 0.05 and ** for P < 0.01. Note that changes in the resting membrane potential were not obtained for all cells within a given drug condition. The numbers in brackets give the actual number of cells for which values were obtained.