Table 3
LSPS-evoked and spontaneous IPSCs
| Layer 2/3 | Layer 5 | |||||
| Sham, n = 13 | FL, n = 13 | P | Sham, n = 12 | FL, n = 12 | P | |
| LSPS-evoked rlIPSCs | ||||||
| Cumulative amplitude/spot (pA) | ||||||
| From all layers | 1.04 ± 1.23 | 1.39 ± 0.23 | - | 3.61 ± 0.48 | 5.89 ± 0.86 | * |
| From layer 2/3 | 1.34 ± 0.22 | 1.84 ± 0.42 | - | 2.46 ± 0.50 | 4.12 ± 0.94 | - |
| From layer 4/5a | 0.61 ± 0.13 | 1.24 ± 0.23 | * | 3.87 ± 0.80 | 8.65 ± 1.71 | * |
| rom layer 5/6 | 1.16 ± 0.24 | 1.09 ± 0.17 | - | 5.03 ± 0.66 | 7.06 ± 1.26 | - |
| Amplitude/kinetics versus number of eventsa | ||||||
| Amplitude (pA) | 11.27 ± 0.86 | 10.43 ± 0.56 | - | 11.03 ± 0.88 | 14.32 ± 1.19 | * |
| 90% rise (ms) | 2.26 ± 0.13 | 2.04 ± 0.10 | - | 2.05 ± 0.10 | 1.97 ± 0.13 | - |
| Half width (ms) | 36.53 ± 3.27 | 33.75 ± 2.48 | - | 26.86 ± 2.57 | 22.92 ± 3.92 | - |
| rlIPSCs/spot | 0.187 ± 0.0029 | 0.265 ± 0.029 | - | 0.360 ± 0.046 | 0.460 ± 0.070 | - |
| LSPS-evoked slIPSC | ||||||
| Amplitude (pA) | 27.46 ± 2.01 | 37.96 ± 4.01 | * | 21.68 ± 3.45 | 30.61 ± 3.78 | - |
| slIPSCs/spot | 0.120 ± 0.018 | 0.145 ± 0.011 | - | 0.183 ± 0.027 | 0.229 ± 0.038 | - |
| Spontaneous IPSC | ||||||
| Amplitude (pA) | 7.77 ± 0.33 | 7.87 ± 0.39 | - | 7.24 ± 0.37 | 8.54 ± 0.30 | * |
| 90% rise (ms) | 1.71 ± 0.07 | 1.66 ± 0.06 | - | 1.74 ± 0.05 | 1.67 ± 0.06 | - |
| Half width (ms) | 30.65 ± 2.19 | 26.91 ± 1.75 | - | 27.37 ± 2.06 | 23.01 ± 2.23 | - |
| Frequency (Hz) | 1.84 ± 0.49 | 2.84 ± 0.46 | - | 4.89 ± 1.07 | 5.67 ± 1.08 | - |
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Note: Origin and properties of spontaneous and LSPS-evoked rlIPSCs, and of slIPSCs onto pyramidal cells in FL and sham-operated cortex.
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↵a Refers to LSPS-evoked EPSCs from all layers. *P < 0.05; -, not significant, P > 0.05.