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Article: Differences in intrinsic properties and local network connectivity of identified layer 5 and layer 6 adult mouse auditory corticothalamic neurons support a dual corticothalamic projection hypothesis.

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Llano DA; Sherman SM
Cereb. Cortex, 2009


Table 1

Summary of comparisons between layer 5 and layer 6 corticothalamic neurons

Layer 5 corticothalamic (n = 47) Layer 6 corticothalamic (n = 24) P value
Ratio of cells with bursting 34/47 0/24 <0.00001
Input resistance (MΩ) 125 ± 41 216 ± 93 <0.001
Resting potential (mV) 60.6 ± 6.1 63.9 ± 7.0 0.06
τmembrane (ms) 17.0 ± 16.5 14.6 ± 5.6 0.134
Ih (pA) 41.7 ± 22.2 14.9 ± 15.3 <0.001
Adaptation index 0.18 ± 0.14 (n = 13) 0.35 ± 0.13 (n = 21) 0.002
Final interspike interval (ms) 48.1 ± 12.2 (n = 13) 43.7 ± 10.8 (n = 21) 0.284
DAP (mV) 2.1 ± 2.5 0.4 ± 1.0 <0.001
AHP (mV) 4.0 ± 3.7 8.8 ± 4.7 <0.001
Cells with layer 1 apical dendrite 10/12 0/9 <0.001
Somatic area (μm2) 193 ± 53 (n = 12) 100 ± 34 (n = 9) <0.001
Apical dendritic radial length (μm) 600 ± 233 233 ± 176 <0.001
Apical dendritic thickness (μm) 3.7 ± 1.4 1.4 ± 0.4 <0.001

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 5 corticothalamic pyramidal neurons input resistance (MΩ) 125.0 ± 41.0 (47) 125.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 6 corticothalamic regular firing pyramidal neurons input resistance (MΩ) 216.0 ± 93.0 (24) 216.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 5 corticothalamic pyramidal neurons resting membrane potential (mV) 60.6 ± 6.1 (47) -60.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 6 corticothalamic regular firing pyramidal neurons resting membrane potential (mV) 63.9 ± 7.0 (24) -63.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 5 corticothalamic pyramidal neurons membrane time constant (ms) 17.0 ± 16.5 (47) 17.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 6 corticothalamic regular firing pyramidal neurons membrane time constant (ms) 14.6 ± 5.6 (24) 14.6 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 5 corticothalamic pyramidal neurons adaptation ratio (1 – first/last ISI) 0.18 ± 0.14 (13) 0.18 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 6 corticothalamic regular firing pyramidal neurons adaptation ratio (1 – first/last ISI) 0.35 ± 0.13 (21) 0.35 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 5 corticothalamic pyramidal neurons ADP amplitude (mV) 2.1 ± 2.5 (47) 2.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 6 corticothalamic regular firing pyramidal neurons ADP amplitude (mV) 0.4 ± 1.0 (24) 0.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 5 corticothalamic pyramidal neurons fast AHP amplitude (mV) 4.0 ± 3.7 (47) 4.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 6 corticothalamic regular firing pyramidal neurons fast AHP amplitude (mV) 8.8 ± 4.7 (24) 8.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 5 corticothalamic pyramidal neurons cell surface area 193.0 ± 53.0 (12) 193.0 (m) Data Table
Neocortex pyramidal cell layer 5-6 Auditory cortex layer 6 corticothalamic regular firing pyramidal neurons cell surface area 100.0 ± 34.0 (9) 100.0 (m) Data Table