AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: A barrel-related interneuron in layer 4 of rat somatosensory cortex with a high intrabarrel connectivity.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Koelbl C; Helmstaedter M; Lübke J; Feldmeyer D
Cereb. Cortex, 2015


Table 1

Intrinsic electrophysiological properties of layer 4 interneurons and excitatory L4 spiny neurons

Parameters Spiny neurons mean ± SD P (spiny neurons vs. L4 IN) Barrel inhibitor Noncluster 3 P (cluster 3 vs. noncluster 3) P (cluster 3 vs. 2) P (cluster 3 vs. 1)
Cluster 3 mean ± SD Cluster 2 mean ± SD Cluster 1 mean ± SD
Morphology
 Total axon length (mm) n/a n/a 16.0 ± 6.0 19.6 ± 7.0 25.5 ± 11.4 ns ns <0.05
 Axon barrel ratio n/a n/a 0.89 ± 0.05 0.66 ± 0.06 0.28 ± 0.11 <0.001 <0.01 <0.001
Static EP
 AP half width (ms) 1.10 ± 0.13 <0.001 0.32 ± 0.08 0.39 ± 0.11 0.34 ± 0.10 0.1 ns ns
 AHP amplitude (mV) -11.8 ± 1.7 <0.01 -16.0 ± 3.5 -13.7 ± 3.8 -15.7 ± 3.7 0.21 ns ns
 AP threshold (mV) -40.8 ± 9.8 0.02 -34.4 ± 7.6 -33.3 ± 6.0 -35.0 ± 5.4 0.99 ns ns
Dynamic EP
 Fmax (Hz) 60 ± 9 <0.001 279 ± 51 293 ± 88 280 ± 56 0.69 ns ns
 Adaptation ratio 0.18 ± 0.10 <0.001 0.67 ± 0.11 0.68 ± 0.14 0.75 ± 0.20 0.29 ns ns
 AHP difference (mV) -7.6 ± 1.6 <0.001 1.1 ± 1.1 1.8 ± 1.1 1.2 ± 0.6 0.25 ns ns
Passive EP
 Baseline Vm (mV) -70.1 ± 8.2 0.10 -67.2 ± 4.9 -67.2 ± 4.8 64.2 ± 7.7 0.35 ns ns
 Membrane resistance (MΩ) 138.9 ± 26.8 <0.001 85 ± 19.8 91.2 ± 21.9 96.2 ± 19.8 0.14 ns ns

  • Different morphological subtypes as defined by cluster analysis are represented by “barrel inhibitor” neurons (cluster 3) and 2 noncluster 3 subgroups (pooled data of cluster 1 and 2 interneurons). There was no difference in any physiological parameter between the 3 different morphological clusters of layer 4 interneurons (ANOVA with Dunn's post-test analysis; ns, nonsignificant). When compared with L4 interneurons (L4 IN), L4 spiny neurons showed differences in all physiological parameters except baseline membrane voltage (n/a, nonapplicable).


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex interneuron deep Somatosensory cortex layer 4 spiny GABAergic excitatory interneuron spike half-width (ms) 1.1 ± 0.13 (45) 1.1 (ms) Data Table
Neocortex interneuron deep Barrel cortex layer 4 fast-spking barrel-confined GABAergic parvalbumin-positive inhibitory interneuron spike half-width (ms) 0.32 ± 0.08 (23) 0.32 (ms) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 2 GABAergic interneuron spike half-width (ms) 0.39 ± 0.11 (11) 0.39 (ms) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 1 GABAergic interneuron spike half-width (ms) 0.34 ± 0.1 (11) 0.34 (ms) Data Table
Neocortex interneuron deep Somatosensory cortex layer 4 spiny GABAergic excitatory interneuron AHP amplitude (mV) -11.8 ± 1.7 (45) 11.8 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 fast-spking barrel-confined GABAergic parvalbumin-positive inhibitory interneuron AHP amplitude (mV) -16.0 ± 3.5 (23) 16.0 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 2 GABAergic interneuron AHP amplitude (mV) -13.7 ± 3.8 (11) 13.7 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 1 GABAergic interneuron AHP amplitude (mV) -15.7 ± 3.7 (11) 15.7 (mV) Data Table
Neocortex interneuron deep Somatosensory cortex layer 4 spiny GABAergic excitatory interneuron spike threshold (mV) -40.8 ± 9.8 (45) -40.8 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 fast-spking barrel-confined GABAergic parvalbumin-positive inhibitory interneuron spike threshold (mV) -34.4 ± 7.6 (23) -34.4 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 2 GABAergic interneuron spike threshold (mV) -33.3 ± 6.0 (11) -33.3 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 1 GABAergic interneuron spike threshold (mV) -35.0 ± 5.4 (11) -35.0 (mV) Data Table
Neocortex interneuron deep Somatosensory cortex layer 4 spiny GABAergic excitatory interneuron maximum firing rate (Hz) 60.0 ± 9.0 (45) 60.0 (Hz) Data Table
Neocortex interneuron deep Barrel cortex layer 4 fast-spking barrel-confined GABAergic parvalbumin-positive inhibitory interneuron maximum firing rate (Hz) 279.0 ± 51.0 (23) 279.0 (Hz) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 2 GABAergic interneuron maximum firing rate (Hz) 293.0 ± 88.0 (11) 293.0 (Hz) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 1 GABAergic interneuron maximum firing rate (Hz) 280.0 ± 56.0 (11) 280.0 (Hz) Data Table
Neocortex interneuron deep Somatosensory cortex layer 4 spiny GABAergic excitatory interneuron adaptation ratio 0.18 ± 0.1 (45) 0.18 (ratio) Data Table
Neocortex interneuron deep Barrel cortex layer 4 fast-spking barrel-confined GABAergic parvalbumin-positive inhibitory interneuron adaptation ratio 0.67 ± 0.11 (23) 0.67 (ratio) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 2 GABAergic interneuron adaptation ratio 0.68 ± 0.14 (11) 0.68 (ratio) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 1 GABAergic interneuron adaptation ratio 0.75 ± 0.2 (11) 0.75 (ratio) Data Table
Neocortex interneuron deep Somatosensory cortex layer 4 spiny GABAergic excitatory interneuron resting membrane potential (mV) -70.1 ± 8.2 (45) -70.1 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 fast-spking barrel-confined GABAergic parvalbumin-positive inhibitory interneuron resting membrane potential (mV) -67.2 ± 4.9 (23) -67.2 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 2 GABAergic interneuron resting membrane potential (mV) -67.2 ± 4.8 (11) -67.2 (mV) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 1 GABAergic interneuron resting membrane potential (mV) 64.2 ± 7.7 (11) -64.2 (mV) Data Table
Neocortex interneuron deep Somatosensory cortex layer 4 spiny GABAergic excitatory interneuron input resistance (MΩ) 138.9 ± 26.8 (45) 138.9 (MΩ) Data Table
Neocortex interneuron deep Barrel cortex layer 4 fast-spking barrel-confined GABAergic parvalbumin-positive inhibitory interneuron input resistance (MΩ) 85.0 ± 19.8 (23) 85.0 (MΩ) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 2 GABAergic interneuron input resistance (MΩ) 91.2 ± 21.9 (11) 91.2 (MΩ) Data Table
Neocortex interneuron deep Barrel cortex layer 4 cluster 1 GABAergic interneuron input resistance (MΩ) 96.2 ± 19.8 (11) 96.2 (MΩ) Data Table