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Article: Morphological and physiological characterization of pyramidal neuron subtypes in rat medial prefrontal cortex.

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van Aerde KI; Feldmeyer D
Cereb. Cortex, 2015


Table 4

Electrophysiological subtypes of L2 pyramidal neurons differ in adaptation ratios, but not in passive electrical properties or morphological parameters

Regular spiking (n = 3) Ad-RS (n = 4) Adapting (n = 8) P
Electrophysiology
 Ratio ISI-1/ISI-9 0.32 ± 0.05* 0.19 ± 0.02 0.15 ± 0.02 <0.05
 Ratio ISI-2/ISI-9 0.71 ± 0.03 0.49 ± 0.07 0.34 ± 0.05 <0.01
 Ratio ISI-3/ISI-9 0.86 ± 0.02 0.82 ± 0.02 0.50 ± 0.06** <0.01
 Increase in firing frequency (Hz/100 pA) 8.1 ± 1.1 5.3 ± 0.4 5.1 ± 0.4 <0.05
 Membrane potential (mV) -78.5 ± 2.5 -74.3 ± 1.0 -77.3 ± 2.8 0.38
 Input resistance (MΩ) 218 ± 65 149 ± 10 162 ± 17 0.15
 Rheobase (pA) 183 ± 43 183 ± 14 203 ± 26 0.79
 Time constant (ms) 17.3 ± 1.2 19.6 ± 1.5 21.8 ± 2.4 0.18
 Voltage sag (%) 1.5 ± 0.8 2.8 ± 0.7 3.7 ± 2.0 0.34
Morphology
 Location in L2 (%) 57 ± 9 75 ± 10 71 ± 11 0.50
 Field span apical dendrites (μm) 290 ± 43 324 ± 29 376 ± 25 0.22
 Field span basal dendrites (μm) 203 ± 9 178 ± 18 213 ± 9 0.21
 Total length apical dendrites (μm) 3066 ± 341 3621 ± 397 3669 ± 521 0.62
 Total length basal dendrites (μm) 1530 ± 230 1452 ± 259 2090 ± 239 0.19
 Soma (μm2) 216 ± 7 196 ± 16 218 ± 9 0.39
 Number of apical branches 28.0 ± 2.1 29.0 ± 4.7 29.5 ± 3.3 0.96
 Number of basal branches 17.0 ± 1.5 17.8 ± 1.6 25.5 ± 4.0 0.12

  • Note: For clarity, the results of the post hoc comparison of groups is only given (values in bold followed with asterisks) when a cell type is different from all other cell types. *P < 0.05, **P < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal regular spiking neuron adaptation ratio 0.32 ± 0.05 (3) 0.32 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal intermediate adapting neuron adaptation ratio 0.19 ± 0.02 (4) 0.19 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal adapting neuron adaptation ratio 0.15 ± 0.02 (8) 0.15 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal regular spiking neuron resting membrane potential (mV) -78.5 ± 2.5 (3) -78.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal intermediate adapting neuron resting membrane potential (mV) -74.3 ± 1.0 (4) -74.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal adapting neuron resting membrane potential (mV) -77.3 ± 2.8 (8) -77.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal regular spiking neuron input resistance (MΩ) 218.0 ± 65.0 (3) 218.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal intermediate adapting neuron input resistance (MΩ) 149.0 ± 10.0 (4) 149.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal adapting neuron input resistance (MΩ) 162.0 ± 17.0 (8) 162.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal regular spiking neuron rheobase (pA) 183.0 ± 43.0 (3) 183.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal intermediate adapting neuron rheobase (pA) 183.0 ± 14.0 (4) 183.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal adapting neuron rheobase (pA) 203.0 ± 26.0 (8) 203.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal regular spiking neuron membrane time constant (ms) 17.3 ± 1.2 (3) 17.3 (ms) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal intermediate adapting neuron membrane time constant (ms) 19.6 ± 1.5 (4) 19.6 (ms) Data Table
Neocortex pyramidal cell layer 2-3 medial prefrontal cortex layer II pyramidal adapting neuron membrane time constant (ms) 21.8 ± 2.4 (8) 21.8 (ms) Data Table