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Article: Ketamine Administration During the Second Postnatal Week Alters Synaptic Properties of Fast-Spiking Interneurons in the Medial Prefrontal Cortex of Adult Mice.

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Jeevakumar V; Kroener S
Cereb. Cortex, 2014


Table 1

Electrophysiological properties of GFP+ interneurons in layer 5 of the medial PFC from mice treated with saline or ketamine during development (means ± standard error)

Saline (n = 16) Ketamine (n = 15) P value
AP threshold (mV) -41.75 ± 1.61 -39.76 ± 1.24 0.34
AP amplitude (mV) 58.21 ± 3.51 58.66 ± 3.07 0.92
AP half width (ms) 0.76 ± 0.03 0.74 ± 0.02 0.55
Input resistance (MΩ) 241.23 ± 24.8 235.78 ± 28.77 0.89
fAHP amplitude (mV) 16.12 ± 1.13 18.32 ± 1.13 0.18

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell medial prefrontal cortex layer 5 fast-spiking parvalbumin positive GFP-expressing interneuron spike half-width (ms) 0.76 ± 0.03 (16) 0.76 (ms) Data Table
Neocortex basket cell medial prefrontal cortex layer 5 fast-spiking parvalbumin positive GFP-expressing interneuron input resistance (MΩ) 241.23 ± 24.8 (16) 241.23 (MΩ) Data Table
Neocortex basket cell medial prefrontal cortex layer 5 fast-spiking parvalbumin positive GFP-expressing interneuron fast AHP amplitude (mV) 16.12 ± 1.13 (16) 16.12 (mV) Data Table
Neocortex basket cell medial prefrontal cortex layer 5 fast-spiking parvalbumin positive GFP-expressing interneuron spike threshold (mV) -41.75 ± 1.61 (16) -41.75 (mV) Data Table
Neocortex basket cell medial prefrontal cortex layer 5 fast-spiking parvalbumin positive GFP-expressing interneuron spike amplitude (mV) 58.21 ± 3.51 (16) 58.21 (mV) Data Table